The bone marrow examination in breast cancer. Diagnostic considerations and clinical usefulness

James N. Ingle, Douglass C. Tormey, Henry K. Tan

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Bone marrow examinations were performed on 116 women with primary and metastatic breast cancer and were correlated with the clinical status of the patient and other specific diagnostic modalities. The relative diagnostic efficacy of the marrow biopsy, aspirate smear and clot section was examined, as was the value of serial marrow examinations. A marrow positive for tumor was found in 40% of those with metastatic disease, 55% with positive x‐rays, 56% with positive bone scans, but only 4% (1/24) with both scan and x‐ray normal. Routine hematologic parameters were of limited usefulness in predicting the finding of a positive marrow. The biopsy was superior to the smear and clot section but aspirated material also had to be analyzed to maximize diagnostic yield. When analyzed qualitatively, i.e., positive or negative for tumor, serial marrow examinations were not useful in assessing the efficacy of antitumor treatment. The potential usefulness of bone marrow examination in patients with breast cancer is discussed.

Original languageEnglish (US)
Pages (from-to)670-674
Number of pages5
JournalCancer
Volume41
Issue number2
DOIs
StatePublished - Feb 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'The bone marrow examination in breast cancer. Diagnostic considerations and clinical usefulness'. Together they form a unique fingerprint.

  • Cite this