The bone marrow examination in breast cancer: Diagnostic considerations and clinical usefulness

J. N. Ingle, D. C. Tormey, H. K. Tan

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Bone marrow examinations were performed on 116 women with primary and metastatic breast cancer and were correlated with the clinical status of the patient and other specific diagnostic modalities. The relative diagnostic efficacy of the marrow biopsy, aspirate smear and clot section was examined, as was the value of serial marrow examinations. A marrow positive for tumor was found in 40% of those with metastatic disease, 55% with positive x-rays, 56% with positive bone scans, but only 4% (1/24) with both scan and x-ray normal. Routine hematologic parameters were of limited usefulness in predicting the finding of a positive marrow. The biopsy was superior to the smear and clot section but aspirated material also had to be analyzed to maximize diagnostic yield. When analyzed qualitatively, i.e., positive or negative for tumor, serial marrow examinations were not useful in assessing the efficacy of antitumor treatment. The potential usefulness of bone marrow examination in patients with breast cancer is discussed.

Original languageEnglish (US)
Pages (from-to)670-674
Number of pages5
JournalCancer
Volume41
Issue number2
StatePublished - 1978

Fingerprint

Bone Marrow Examination
Bone Marrow
Breast Neoplasms
X-Rays
Biopsy
Neoplasms
Bone and Bones

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ingle, J. N., Tormey, D. C., & Tan, H. K. (1978). The bone marrow examination in breast cancer: Diagnostic considerations and clinical usefulness. Cancer, 41(2), 670-674.

The bone marrow examination in breast cancer : Diagnostic considerations and clinical usefulness. / Ingle, J. N.; Tormey, D. C.; Tan, H. K.

In: Cancer, Vol. 41, No. 2, 1978, p. 670-674.

Research output: Contribution to journalArticle

Ingle, JN, Tormey, DC & Tan, HK 1978, 'The bone marrow examination in breast cancer: Diagnostic considerations and clinical usefulness', Cancer, vol. 41, no. 2, pp. 670-674.
Ingle, J. N. ; Tormey, D. C. ; Tan, H. K. / The bone marrow examination in breast cancer : Diagnostic considerations and clinical usefulness. In: Cancer. 1978 ; Vol. 41, No. 2. pp. 670-674.
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