TY - JOUR
T1 - The bone marrow-cardiac axis
T2 - Role of endothelial progenitor cells in heart failure
AU - Maltais, Simon
AU - Perrault, Louis P.
AU - Ly, Hung Q.
N1 - Funding Information:
§ Dr Perrault is supported by the National Institute of Health (NIH) and the Department of Surgery, Université de Montréal. Dr Ly is supported by the Heart and Stroke Foundation of Canada (HSFC) and the Stem Cell Network of Canada. * Corresponding author. Address: Department of Medicine, Montreal Heart Institute, Université de Montréal, 5000 Belanger St. (East), Montréal, Québec, Canada H1T 1C8. Tel.: +1 514 376 3330/2438; fax: +1 514 593 6299. E-mail address: qh.ly@umontreal.ca (H.Q. Ly).
PY - 2011/3
Y1 - 2011/3
N2 - Congestive heart failure (CHF) remains a leading cause of mortality in the developed world. The complex mechanisms involved in the pathophysiology of heart failure (HF) explain some of the limited impact of current recognised therapeutic strategies. There is, therefore, a definite need for new alternative molecular and biological pathways to address the treatment of this condition. Over the past decade, much research has focussed upon identifying the ideal cell type to promote myocardial regeneration. Recently, striking reports suggested the concept that bone-marrow (BM)-derived endothelial progenitor cells (EPCs) participate in cardiac regeneration and function recovery in the setting of progressive HF. The modulation of this complex interaction between the BM and the circulating EPCs could be at the crossroad of multiple therapeutic strategies aimed to protect or restore the myocardium in the setting of the CHF. However, there are uncertainties and unresolved issues regarding the mechanisms possibly responsible for the functional benefits observed in chronic experimental and pre-clinical studies. Hence, the BM-cardiac axis concept has created overwhelming enthusiasm and subsequent scepticism in the field of cardiac repair and regeneration. Further intensive research in basic science and clinical arenas are needed to elucidate the potential association between BM and heart function recovery, particularly in the progression towards advance stages of CHF. In this review, we focus on the importance of the BM-cardiac axis and BM-derived EPCs in the pathophysiology, clinical progression and potential treatment of CHF.
AB - Congestive heart failure (CHF) remains a leading cause of mortality in the developed world. The complex mechanisms involved in the pathophysiology of heart failure (HF) explain some of the limited impact of current recognised therapeutic strategies. There is, therefore, a definite need for new alternative molecular and biological pathways to address the treatment of this condition. Over the past decade, much research has focussed upon identifying the ideal cell type to promote myocardial regeneration. Recently, striking reports suggested the concept that bone-marrow (BM)-derived endothelial progenitor cells (EPCs) participate in cardiac regeneration and function recovery in the setting of progressive HF. The modulation of this complex interaction between the BM and the circulating EPCs could be at the crossroad of multiple therapeutic strategies aimed to protect or restore the myocardium in the setting of the CHF. However, there are uncertainties and unresolved issues regarding the mechanisms possibly responsible for the functional benefits observed in chronic experimental and pre-clinical studies. Hence, the BM-cardiac axis concept has created overwhelming enthusiasm and subsequent scepticism in the field of cardiac repair and regeneration. Further intensive research in basic science and clinical arenas are needed to elucidate the potential association between BM and heart function recovery, particularly in the progression towards advance stages of CHF. In this review, we focus on the importance of the BM-cardiac axis and BM-derived EPCs in the pathophysiology, clinical progression and potential treatment of CHF.
KW - Bone marrow axis
KW - Heart failure
KW - Progenitor cells
KW - Therapy
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U2 - 10.1016/j.ejcts.2010.04.022
DO - 10.1016/j.ejcts.2010.04.022
M3 - Review article
C2 - 20663680
AN - SCOPUS:79951512405
SN - 1010-7940
VL - 39
SP - 368
EP - 374
JO - European Journal of Cardio-Thoracic Surgery
JF - European Journal of Cardio-Thoracic Surgery
IS - 3
ER -