TY - JOUR
T1 - The blood transfer conductance for nitric oxide
T2 - Infinite vs. finite θNO
AU - Coffman, Kirsten E.
AU - Chase, Steven C.
AU - Taylor, Bryan J.
AU - Johnson, Bruce D.
N1 - Funding Information:
KEC and SCC are supported by Mayo Graduate School. KEC is supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health grant F31HL131076. BJT is supported by a Fulbright Commission UK Distinguished Scholar Award and American Heart Association Grant AHA12-POST12070084. This study was funded by NIH grant HL71478.
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/7
Y1 - 2017/7
N2 - Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). In this review, we discuss the background associated with θNO, explore the resulting values of DmCO and VC when applying either assumption, and investigate the mathematical underpinnings of DmCO and VC calculations. In general, both assumptions yield reasonable rest and exercise DmCO and VC values. However, the finite θNO assumption demonstrates increasing VC, but not DmCO, with submaximal exercise. At relatively high, but physiologic, DLNO/DLCO ratios both assumptions can result in asymptotic behavior for VC values, and under the finite θNO assumption, DmCO values. In conclusion, we feel that the assumptions associated with a finite θNO require further in vivo validation against an established method before widespread research and clinical use.
AB - Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). In this review, we discuss the background associated with θNO, explore the resulting values of DmCO and VC when applying either assumption, and investigate the mathematical underpinnings of DmCO and VC calculations. In general, both assumptions yield reasonable rest and exercise DmCO and VC values. However, the finite θNO assumption demonstrates increasing VC, but not DmCO, with submaximal exercise. At relatively high, but physiologic, DLNO/DLCO ratios both assumptions can result in asymptotic behavior for VC values, and under the finite θNO assumption, DmCO values. In conclusion, we feel that the assumptions associated with a finite θNO require further in vivo validation against an established method before widespread research and clinical use.
KW - Alveolar capillary membrane conductance
KW - Exercise
KW - In vivo validation
KW - Lung diffusing capacity
KW - Pulmonary capillary blood volume
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U2 - 10.1016/j.resp.2016.12.007
DO - 10.1016/j.resp.2016.12.007
M3 - Article
C2 - 28013060
AN - SCOPUS:85009727217
VL - 241
SP - 45
EP - 52
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
ER -