The biology and mathematical modelling of glioma invasion: A review

J. C.L. Alfonso, K. Talkenberger, M. Seifert, B. Klink, A. Hawkins-Daarud, Kristin Swanson, H. Hatzikirou, A. Deutsch

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low-To high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.

Original languageEnglish (US)
Article number20170490
JournalJournal of the Royal Society Interface
Volume14
Issue number136
DOIs
StatePublished - Nov 1 2017

Fingerprint

Glioma
Tumors
Brain
Mathematical models
Theoretical Models
Neoplasms
Infiltration
Plasticity
Life Expectancy
Brain Neoplasms
Tissue
Survival Rate
Therapeutics

Keywords

  • Cell phenotypic plasticity
  • Glioma invasion
  • Infiltrative tumour morphology
  • Malignant progression
  • Mathematical modelling

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Alfonso, J. C. L., Talkenberger, K., Seifert, M., Klink, B., Hawkins-Daarud, A., Swanson, K., ... Deutsch, A. (2017). The biology and mathematical modelling of glioma invasion: A review. Journal of the Royal Society Interface, 14(136), [20170490]. https://doi.org/10.1098/rsif.2017.0490

The biology and mathematical modelling of glioma invasion : A review. / Alfonso, J. C.L.; Talkenberger, K.; Seifert, M.; Klink, B.; Hawkins-Daarud, A.; Swanson, Kristin; Hatzikirou, H.; Deutsch, A.

In: Journal of the Royal Society Interface, Vol. 14, No. 136, 20170490, 01.11.2017.

Research output: Contribution to journalReview article

Alfonso, JCL, Talkenberger, K, Seifert, M, Klink, B, Hawkins-Daarud, A, Swanson, K, Hatzikirou, H & Deutsch, A 2017, 'The biology and mathematical modelling of glioma invasion: A review', Journal of the Royal Society Interface, vol. 14, no. 136, 20170490. https://doi.org/10.1098/rsif.2017.0490
Alfonso JCL, Talkenberger K, Seifert M, Klink B, Hawkins-Daarud A, Swanson K et al. The biology and mathematical modelling of glioma invasion: A review. Journal of the Royal Society Interface. 2017 Nov 1;14(136). 20170490. https://doi.org/10.1098/rsif.2017.0490
Alfonso, J. C.L. ; Talkenberger, K. ; Seifert, M. ; Klink, B. ; Hawkins-Daarud, A. ; Swanson, Kristin ; Hatzikirou, H. ; Deutsch, A. / The biology and mathematical modelling of glioma invasion : A review. In: Journal of the Royal Society Interface. 2017 ; Vol. 14, No. 136.
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