The biological role of mucins in cellular interactions and immune regulation: Prospects for cancer immunotherapy

Babita Agrawal, Sandra J Gendler, B. Michael Longenecker

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Among the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 antibody and cytotoxic T lymphocyte responses. Recently, a novel immunoregulatory role for MUC1 has been suggested by experiments demonstrating that soluble MUC1 induces T-cell unresponsiveness, and that T cells appear to express and secrete MUC1 following their activation. MUC1 is an apparent paradox, having both adhesive and antiadhesive functions, and immunostimulatory and immunosuppressive activities.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalMolecular Medicine Today
Volume4
Issue number9
DOIs
StatePublished - Sep 1 1998

Fingerprint

Mucins
Immunotherapy
T-Lymphocytes
Neoplasms
Cytotoxic T-Lymphocytes
Immunosuppressive Agents
Adhesives
Anti-Idiotypic Antibodies
Immunization
Signal Transduction
Peptides

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine

Cite this

The biological role of mucins in cellular interactions and immune regulation : Prospects for cancer immunotherapy. / Agrawal, Babita; Gendler, Sandra J; Longenecker, B. Michael.

In: Molecular Medicine Today, Vol. 4, No. 9, 01.09.1998, p. 397-403.

Research output: Contribution to journalArticle

@article{ff4d6ed183964ca2ad24e7258a61532a,
title = "The biological role of mucins in cellular interactions and immune regulation: Prospects for cancer immunotherapy",
abstract = "Among the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 antibody and cytotoxic T lymphocyte responses. Recently, a novel immunoregulatory role for MUC1 has been suggested by experiments demonstrating that soluble MUC1 induces T-cell unresponsiveness, and that T cells appear to express and secrete MUC1 following their activation. MUC1 is an apparent paradox, having both adhesive and antiadhesive functions, and immunostimulatory and immunosuppressive activities.",
author = "Babita Agrawal and Gendler, {Sandra J} and Longenecker, {B. Michael}",
year = "1998",
month = "9",
day = "1",
doi = "10.1016/S1357-4310(98)01322-7",
language = "English (US)",
volume = "4",
pages = "397--403",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - The biological role of mucins in cellular interactions and immune regulation

T2 - Prospects for cancer immunotherapy

AU - Agrawal, Babita

AU - Gendler, Sandra J

AU - Longenecker, B. Michael

PY - 1998/9/1

Y1 - 1998/9/1

N2 - Among the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 antibody and cytotoxic T lymphocyte responses. Recently, a novel immunoregulatory role for MUC1 has been suggested by experiments demonstrating that soluble MUC1 induces T-cell unresponsiveness, and that T cells appear to express and secrete MUC1 following their activation. MUC1 is an apparent paradox, having both adhesive and antiadhesive functions, and immunostimulatory and immunosuppressive activities.

AB - Among the human mucins, MUC1 is unique in its cell-surface transmembrane expression and its apparent signal-transduction functions. The high expression of MUC1 on many human cancers makes it an attractive target for immunotherapy. Immunization of human cancer patients with MUC1 peptides has resulted in the generation of both anti-MUC1 antibody and cytotoxic T lymphocyte responses. Recently, a novel immunoregulatory role for MUC1 has been suggested by experiments demonstrating that soluble MUC1 induces T-cell unresponsiveness, and that T cells appear to express and secrete MUC1 following their activation. MUC1 is an apparent paradox, having both adhesive and antiadhesive functions, and immunostimulatory and immunosuppressive activities.

UR - http://www.scopus.com/inward/record.url?scp=0031665243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031665243&partnerID=8YFLogxK

U2 - 10.1016/S1357-4310(98)01322-7

DO - 10.1016/S1357-4310(98)01322-7

M3 - Article

C2 - 9791863

AN - SCOPUS:0031665243

VL - 4

SP - 397

EP - 403

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 9

ER -