The B7 Homologues and their Receptors in Hematologic Malignancies

Ryan A. Wilcox, Stephen M. Ansell, Megan S. Lim, Weiping Zou, Lieping Chen

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The B7 homologues and their receptors regulate both peripheral tolerance and adaptive immunity. This field is rapidly evolving as new ligands and receptors are being identified. Much of the work supporting their role in the regulation of host anti-tumor immunity has been derived from experimental models and clinical trials in solid malignancies. However, a growing body of evidence demonstrates that the B7-H family has important immunologic and non-immunologic functions in a variety of hematologic malignancies. Herein, we will review recent evidence that supports the therapeutic targeting of the B7 homologues in hematologic malignancies.

Original languageEnglish (US)
Pages (from-to)465-475
Number of pages11
JournalEuropean Journal of Haematology
Volume88
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • B7-H1
  • Costimulation
  • Leukemia
  • Lymphoma
  • PD-1
  • T cell

ASJC Scopus subject areas

  • Hematology

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