The association of transient ischemic attack symptoms with memory impairment among elderly participants of the third US national health and nutrition examination survey

Paul Y Takahashi, Liselotte (Lotte) Dyrbye, Kris G. Thomas, Onelis Quirindongo Cedeno, Frederick North, Robert J. Stroebel, Ramona S. Dejesus, Paul V. Targonski

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background and Purpose: Stroke is a well-known risk factor for vascular dementia. However, the association of transient ischemic attacks with cognitive impairment is less well-established. Methods: Records from Third National Health and Nutrition Examination Survey were abstracted for demographic and medical information for participants with an age !60 years who reported being free of stroke. Five self-reported symptoms (weakness, numbness, loss of vision, inability to speak, and severe dizziness) were used as surrogates representing transient ischemic attacks. Information on conventional risk factors for vascular dementia was also obtained. Multivariable logistic regression was used to examine risk factors for memory impairment. Results: 4617 participants were included with a sample-weighted prevalence of memory impairment of 6.6% (1417 participants). The final multivariable analysis revealed a significant association between transient weakness and memory impairment (odds ratio 1.52, 95% CI 1.11-2.07). The other 4 transient ischemic attacks symptoms were not significantly associated with memory impairment in the final model. Systolic blood pressure >140 was most strongly associated with prevalent memory impairment (odds ratio, 9.78, 95% CI 1.49-64.3). Other associated risk factors included non-white race, male gender, age, education ≤12 years, and history of any alcohol use. Conclusion: Among transient ischemic attacks symptoms, self-reported weakness in the face, arm, or leg was significantly associated with memory impairment. This study indicates that transient ischemic attacks symptoms are, even in the absence of stroke, associated with memory impairment. Aggressive risk factor modification in patients with TIA symptoms may be warranted to prevent potential future memory loss.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalJournal of Geriatric Psychiatry and Neurology
Volume22
Issue number1
DOIs
StatePublished - Mar 2009

Fingerprint

Nutrition Surveys
Transient Ischemic Attack
Vascular Dementia
Stroke
Odds Ratio
Blood Pressure
Hypesthesia
Memory Disorders
Dizziness
Leg
Arm
Logistic Models
Alcohols
Demography
Education

Keywords

  • Memory impairment
  • NHANES III
  • Transient ischemic attack

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology
  • Geriatrics and Gerontology

Cite this

The association of transient ischemic attack symptoms with memory impairment among elderly participants of the third US national health and nutrition examination survey. / Takahashi, Paul Y; Dyrbye, Liselotte (Lotte); Thomas, Kris G.; Quirindongo Cedeno, Onelis; North, Frederick; Stroebel, Robert J.; Dejesus, Ramona S.; Targonski, Paul V.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 22, No. 1, 03.2009, p. 46-51.

Research output: Contribution to journalArticle

Takahashi, Paul Y ; Dyrbye, Liselotte (Lotte) ; Thomas, Kris G. ; Quirindongo Cedeno, Onelis ; North, Frederick ; Stroebel, Robert J. ; Dejesus, Ramona S. ; Targonski, Paul V. / The association of transient ischemic attack symptoms with memory impairment among elderly participants of the third US national health and nutrition examination survey. In: Journal of Geriatric Psychiatry and Neurology. 2009 ; Vol. 22, No. 1. pp. 46-51.
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