@article{1a4ea4f6038b4afda7f9ed7f07e650b5,
title = "The association of telomere length with colorectal cancer differs by the age of cancer onset",
abstract = "OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length. METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls. RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (r50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (450 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner. CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.",
author = "Boardman, {Lisa A.} and Kristin Litzelman and Songwon Seo and Johnson, {Ruth A.} and Vanderboom, {Russell J.} and Kimmel, {Grace W.} and Cunningham, {Julie M.} and Gangnon, {Ronald E.} and Engelman, {Corinne D.} and Riegert-Johnson, {Douglas L.} and John Potter and Robert Haile and Daniel Buchanan and Jenkins, {Mark A.} and Rider, {David N.} and Thibodeau, {Stephen N.} and Petersen, {Gloria M.} and Skinner, {Halcyon G.}",
note = "Funding Information: L. Boardman, K. Litzelman, and H.G. Skinner. Acquisition of data (accrued and managed patients, performed experimental procedures, etc.): L. Boardman, R.A. Johnson, G.W. Kimmel, J.M. Cunningham, J. Potter, R. Haile, D. Buchanan, M.A. Jenkins, and J. Baron. Management and analysis of data: S. Seo, K. Litzelman, C. Engelman, H. Skinner, D.L. Riegert-Johnson, R.E. Gangnon, and G.W. Kimmel. Writing, review, and/or revision of the manuscript: L.A. Boardman, H. Skinner, K. Litzelman, S.N. Thibodeau, G.M. Petersen, J.M. Cunningham, D.N. Rider and R.J. Vanderboom. Administrative, technical, or material support (i.e., reporting or organizing data, constructing databases): D.N. Rider, S. Seo, and K. Litzelman. Study supervision: L.A. Boardman and H.G. Skinner. Financial support: This work was supported by RO-1 CA132718 and P50 CA102701 (Mayo Clinic SPORE in Pancreatic Cancer) through the National Cancer Institute (NCI); P30 DK084567 (Mayo Clinic Center for Cell Signaling in Gastroenterology) through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the Lustgarten Foundation for Pancreatic Cancer Research; the Mayo Clinic Center for Individualized Medicine; National Institutes of Health under RFA # CA-96-011 and through cooperative agreements with the Australasian Colorectal Cancer Family Registry (U01 CA097735); Familial Colorectal Neoplasia Collaborative Group (U01 CA074799) (USC); Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01 CA074800); Ontario Registry for Studies of Familial Colorectal Cancer (U01 CA074783); Seattle Colorectal Cancer Family Registry (U01 CA074794); University of Hawaii Colorectal Cancer Family Registry (U01 CA074806). Potential competing interests: None. Publisher Copyright: {\textcopyright} 2014 the American College of Gastroenterology All rights reserved.",
year = "2014",
month = jan,
day = "1",
doi = "10.1038/ctg.2014.3",
language = "English (US)",
volume = "5",
journal = "Clinical and Translational Gastroenterology",
issn = "2155-384X",
publisher = "Nature Publishing Group",
number = "3",
}