The association of telomere length with colorectal cancer differs by the age of cancer onset

Lisa Allyn Boardman, Kristin Litzelman, Songwon Seo, Ruth A. Johnson, Russell J. Vanderboom, Grace W. Kimmel, Julie M Cunningham, Ronald E. Gangnon, Corinne D. Engelman, Douglas L. Riegert-Johnson, John Potter, Robert Haile, Daniel Buchanan, Mark A. Jenkins, David N. Rider, Stephen N Thibodeau, Gloria M Petersen, Halcyon G. Skinner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length. METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls. RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (r50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (450 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner. CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.

Original languageEnglish (US)
Article numbere52
JournalClinical and Translational Gastroenterology
Volume5
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Telomere
Age of Onset
Colorectal Neoplasms
Neoplasms
Leukocytes
Telomere Shortening
Nucleoproteins
Cell Division
Case-Control Studies
Multivariate Analysis
Chromosomes
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The association of telomere length with colorectal cancer differs by the age of cancer onset. / Boardman, Lisa Allyn; Litzelman, Kristin; Seo, Songwon; Johnson, Ruth A.; Vanderboom, Russell J.; Kimmel, Grace W.; Cunningham, Julie M; Gangnon, Ronald E.; Engelman, Corinne D.; Riegert-Johnson, Douglas L.; Potter, John; Haile, Robert; Buchanan, Daniel; Jenkins, Mark A.; Rider, David N.; Thibodeau, Stephen N; Petersen, Gloria M; Skinner, Halcyon G.

In: Clinical and Translational Gastroenterology, Vol. 5, No. 3, e52, 01.01.2014.

Research output: Contribution to journalArticle

Boardman, LA, Litzelman, K, Seo, S, Johnson, RA, Vanderboom, RJ, Kimmel, GW, Cunningham, JM, Gangnon, RE, Engelman, CD, Riegert-Johnson, DL, Potter, J, Haile, R, Buchanan, D, Jenkins, MA, Rider, DN, Thibodeau, SN, Petersen, GM & Skinner, HG 2014, 'The association of telomere length with colorectal cancer differs by the age of cancer onset', Clinical and Translational Gastroenterology, vol. 5, no. 3, e52. https://doi.org/10.1038/ctg.2014.3
Boardman, Lisa Allyn ; Litzelman, Kristin ; Seo, Songwon ; Johnson, Ruth A. ; Vanderboom, Russell J. ; Kimmel, Grace W. ; Cunningham, Julie M ; Gangnon, Ronald E. ; Engelman, Corinne D. ; Riegert-Johnson, Douglas L. ; Potter, John ; Haile, Robert ; Buchanan, Daniel ; Jenkins, Mark A. ; Rider, David N. ; Thibodeau, Stephen N ; Petersen, Gloria M ; Skinner, Halcyon G. / The association of telomere length with colorectal cancer differs by the age of cancer onset. In: Clinical and Translational Gastroenterology. 2014 ; Vol. 5, No. 3.
@article{1a4ea4f6038b4afda7f9ed7f07e650b5,
title = "The association of telomere length with colorectal cancer differs by the age of cancer onset",
abstract = "OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length. METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls. RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (r50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (450 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner. CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.",
author = "Boardman, {Lisa Allyn} and Kristin Litzelman and Songwon Seo and Johnson, {Ruth A.} and Vanderboom, {Russell J.} and Kimmel, {Grace W.} and Cunningham, {Julie M} and Gangnon, {Ronald E.} and Engelman, {Corinne D.} and Riegert-Johnson, {Douglas L.} and John Potter and Robert Haile and Daniel Buchanan and Jenkins, {Mark A.} and Rider, {David N.} and Thibodeau, {Stephen N} and Petersen, {Gloria M} and Skinner, {Halcyon G.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1038/ctg.2014.3",
language = "English (US)",
volume = "5",
journal = "Clinical and Translational Gastroenterology",
issn = "2155-384X",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - The association of telomere length with colorectal cancer differs by the age of cancer onset

AU - Boardman, Lisa Allyn

AU - Litzelman, Kristin

AU - Seo, Songwon

AU - Johnson, Ruth A.

AU - Vanderboom, Russell J.

AU - Kimmel, Grace W.

AU - Cunningham, Julie M

AU - Gangnon, Ronald E.

AU - Engelman, Corinne D.

AU - Riegert-Johnson, Douglas L.

AU - Potter, John

AU - Haile, Robert

AU - Buchanan, Daniel

AU - Jenkins, Mark A.

AU - Rider, David N.

AU - Thibodeau, Stephen N

AU - Petersen, Gloria M

AU - Skinner, Halcyon G.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length. METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls. RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (r50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (450 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner. CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.

AB - OBJECTIVES: Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study was to assess the association of CRC and telomere length. METHODS: In this case-control study, we measured relative telomere length from peripheral blood leukocytes (PBLs) DNA with quantitative PCR in 598 CRC patients and 2,212 healthy controls. RESULTS: Multivariate analysis indicated that telomere length was associated with risk for CRC, and this association varied in an age-related manner; younger individuals (r50 years of age) with longer telomeres (80-99 percentiles) had a 2-6 times higher risk of CRC, while older individuals (450 years of age) with shortened telomeres (1-10 percentiles) had 2-12 times the risk for CRC. The risk for CRC varies with extremes in telomere length in an age-associated manner. CONCLUSIONS: Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.

UR - http://www.scopus.com/inward/record.url?scp=84904696144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904696144&partnerID=8YFLogxK

U2 - 10.1038/ctg.2014.3

DO - 10.1038/ctg.2014.3

M3 - Article

AN - SCOPUS:84904696144

VL - 5

JO - Clinical and Translational Gastroenterology

JF - Clinical and Translational Gastroenterology

SN - 2155-384X

IS - 3

M1 - e52

ER -