The association of pauciarticular juvenile arthritis and myasthenia gravis

J. B. Glass, P. K. Sher, Vanda A Lennon, W. E. Regelmann

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We encountered two children with fluorescent antinuclear antibody-positive pauciarticular juvenile arthritis who later developed myasthenia gravis. Acetylcholine receptor binding, blocking, and modulating antibodies, retrospectively tested on frozen serum, yielded negative results before the onset of myasthenic symptoms but all yielded strongly positive results coincident with the onset of weakness. In both children, myasthenia gravis responded to thymectomy, and one child had a beneficial response to plasmapheresis. Although, to our knowledge, only two patients with juvenile arthritis and myasthenia gravis have been described in the past, the presence of two additional children with both diseases in a single clinic population suggests that the association may be more prevalent than previously suspected.

Original languageEnglish (US)
Pages (from-to)1176-1180
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume145
Issue number10
StatePublished - 1991

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Juvenile Arthritis
Myasthenia Gravis
Thymectomy
Blocking Antibodies
Plasmapheresis
Antinuclear Antibodies
Muscle Weakness
Cholinergic Receptors
Serum
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The association of pauciarticular juvenile arthritis and myasthenia gravis. / Glass, J. B.; Sher, P. K.; Lennon, Vanda A; Regelmann, W. E.

In: American Journal of Diseases of Children, Vol. 145, No. 10, 1991, p. 1176-1180.

Research output: Contribution to journalArticle

Glass, J. B. ; Sher, P. K. ; Lennon, Vanda A ; Regelmann, W. E. / The association of pauciarticular juvenile arthritis and myasthenia gravis. In: American Journal of Diseases of Children. 1991 ; Vol. 145, No. 10. pp. 1176-1180.
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