The Association of Pauciarticular Juvenile Arthritis and Myasthenia Gravis

John B. Glass, Phyllis K. Sher, Vanda A. Lennon, Warren E. Regelmann

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We encountered two children with fluorescent antinuclear antibody—positive pauciarticular juvenile arthritis who later developed myasthenia gravis. Acetylcholine receptor binding, blocking, and modulating antibodies, retrospectively tested on frozen serum, yielded negative results before the onset of myasthenic symptoms but all yielded strongly positive results coincident with the onset of weakness. In both children, myasthenia gravis responded to thymectomy, and one child had a beneficial response to plasmapheresis. Although, to our knowledge, only two patients with juvenile arthritis and myasthenia gravis have been described in the past, the presence of two additional children with both diseases in a single clinic population suggests that the association may be more prevalent than previously suspected.

Original languageEnglish (US)
Pages (from-to)1176-1180
Number of pages5
JournalAmerican Journal of Diseases of Children
Volume145
Issue number10
DOIs
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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