The association of nephrolithiasis and autosomal polycystic kidney disease

Vicente Torres, S. B. Erickson, L. H. Smith, D. M. Wilson, R. R. Hattery, J. W. Segura

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Despite the frequency and morbidity of nephrolithiasis in autosomal dominant polycystic kidney disease (ADPKD), this association has not been subject to a detailed study. One hundred fifty-one of 751 ADPKD patients seen at the Mayo Clinic between 1976 and 1986 had nephrolithiasis. Seventy-four had passed calculi or had stones surgically removed. Stone analysis was available in 30 patients: uric acid, calcium oxalate, calcium phosphate, and struvite were present in 56.6%, 46.6%, 20%, and 10%, respectively. Calculi were observed in 71 of 79 patients with excretory urograms available for review. Faintly opaque and bull's eye stones, probably containing uric acid, were present in 12.7% and 14.1% of these patients, respectively. Precaliceal tubular ectasia was observed in 15.5%. Ninety-seven patients had preserved renal function (serum creatinine < 1.5 mg/dL) at the initial evaluation. Six were excluded because they had other known causes of stone disease. The most common metabolic abnormality in the remaining 91 patients was hypocitric aciduria (ten of 15 patients with measurements). The urine pH in the first voided morning specimens (5.66 ± 0.05) was significantly lower than that of an unselected control population (5.92 ± 0.03, P < 0.001). Hyperuricosuria, hyperoxaluria, and hypercalciuria were observed in six of 32 (18.8%), six of 31 (19.4%), and three of 39 (9.7%) patients with preserved renal function. The composition of the stones, the frequency of hypocitric aciduria, and the low urine pH (possibly related to the defect in excretion of ammonia described in ADPKD), suggest that metabolic, along with mechanical, factors are responsible for the frequent occurrence of nephrolithiasis in this disease.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume11
Issue number4
StatePublished - 1988

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Nephrolithiasis
Polycystic Kidney Diseases
Autosomal Dominant Polycystic Kidney
Calculi
Uric Acid
Urine
Hyperoxaluria
Kidney
Hypercalciuria
Pathologic Dilatations
Calcium Oxalate
Urography
Ammonia
Creatinine
Morbidity

ASJC Scopus subject areas

  • Nephrology

Cite this

Torres, V., Erickson, S. B., Smith, L. H., Wilson, D. M., Hattery, R. R., & Segura, J. W. (1988). The association of nephrolithiasis and autosomal polycystic kidney disease. American Journal of Kidney Diseases, 11(4), 318-325.

The association of nephrolithiasis and autosomal polycystic kidney disease. / Torres, Vicente; Erickson, S. B.; Smith, L. H.; Wilson, D. M.; Hattery, R. R.; Segura, J. W.

In: American Journal of Kidney Diseases, Vol. 11, No. 4, 1988, p. 318-325.

Research output: Contribution to journalArticle

Torres, V, Erickson, SB, Smith, LH, Wilson, DM, Hattery, RR & Segura, JW 1988, 'The association of nephrolithiasis and autosomal polycystic kidney disease', American Journal of Kidney Diseases, vol. 11, no. 4, pp. 318-325.
Torres V, Erickson SB, Smith LH, Wilson DM, Hattery RR, Segura JW. The association of nephrolithiasis and autosomal polycystic kidney disease. American Journal of Kidney Diseases. 1988;11(4):318-325.
Torres, Vicente ; Erickson, S. B. ; Smith, L. H. ; Wilson, D. M. ; Hattery, R. R. ; Segura, J. W. / The association of nephrolithiasis and autosomal polycystic kidney disease. In: American Journal of Kidney Diseases. 1988 ; Vol. 11, No. 4. pp. 318-325.
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