The association of ménétrier disease with ulcerative colitis: A case report with implications on the pathogenesis of ménétrier disease

Vien X. Nguyen, Cuong C Nguyen, Jonathan A Leighton, Shabana F Pasha, Alvin C Silva, Jacques P. Heppell, Giovanni De Petris

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalCase Reports in Gastroenterology
Volume4
Issue number1
DOIs
StatePublished - 2010

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Ulcerative Colitis
Transforming Growth Factor alpha
Gastric Mucosa
Stomach
Hypertrophy
Therapeutics

Keywords

  • Cetuximab
  • Epidermal growth factor receptor
  • Ménétrier disease
  • Transforming growth factor-alpha
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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abstract = "M{\'e}n{\'e}trier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.",
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AU - Nguyen, Cuong C

AU - Leighton, Jonathan A

AU - Pasha, Shabana F

AU - Silva, Alvin C

AU - Heppell, Jacques P.

AU - De Petris, Giovanni

PY - 2010

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