The association of ménétrier disease with ulcerative colitis: A case report with implications on the pathogenesis of ménétrier disease

Vien X. Nguyen, Cuong C. Nguyen, Jonathan A. Leighton, Shabana F. Pasha, Alvin C. Silva, Jacques P. Heppell, Giovanni De Petris

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.

Original languageEnglish (US)
Pages (from-to)66-70
Number of pages5
JournalCase Reports in Gastroenterology
Volume4
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Cetuximab
  • Epidermal growth factor receptor
  • Ménétrier disease
  • Transforming growth factor-alpha
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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