The association of ménétrier disease with ulcerative colitis: A case report with implications on the pathogenesis of ménétrier disease

Vien X. Nguyen; Cuong C. Nguyen; Jonathan A. Leighton; Shabana F. Pasha; Alvin C. Silva; Jacques P. Heppell; Giovanni De Petris

doi:10.1159/000255981

The association of ménétrier disease with ulcerative colitis: A case report with implications on the pathogenesis of ménétrier disease

Vien X. Nguyen, Cuong C. Nguyen, Jonathan A. Leighton, Shabana F. Pasha, Alvin C. Silva, Jacques P. Heppell, Giovanni De Petris

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10 Scopus citations

Abstract

Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.

Original language	English (US)
Pages (from-to)	66-70
Number of pages	5
Journal	Case Reports in Gastroenterology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1159/000255981
State	Published - 2010

Keywords

Cetuximab
Epidermal growth factor receptor
Ménétrier disease
Transforming growth factor-alpha
Ulcerative colitis

ASJC Scopus subject areas

Gastroenterology

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10.1159/000255981

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title = "The association of m{\'e}n{\'e}trier disease with ulcerative colitis: A case report with implications on the pathogenesis of m{\'e}n{\'e}trier disease",

abstract = "M{\'e}n{\'e}trier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.",

keywords = "Cetuximab, Epidermal growth factor receptor, M{\'e}n{\'e}trier disease, Transforming growth factor-alpha, Ulcerative colitis",

author = "Nguyen, {Vien X.} and Nguyen, {Cuong C.} and Leighton, {Jonathan A.} and Pasha, {Shabana F.} and Silva, {Alvin C.} and Heppell, {Jacques P.} and {De Petris}, Giovanni",

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AU - Nguyen, Vien X.

AU - Nguyen, Cuong C.

AU - Leighton, Jonathan A.

AU - Pasha, Shabana F.

AU - Silva, Alvin C.

AU - Heppell, Jacques P.

AU - De Petris, Giovanni

PY - 2010

Y1 - 2010

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AB - Ménétrier disease (MD) is a rare hypertrophic condition of the gastric mucosa. The unusual association of MD with ulcerative colitis (UC) has been reported in the literature in eight cases. Transforming growth factor-alpha (TGF-alpha) is overexpressed in UC and appears to play a role in colonic healing and repair. Overproduction of TGF-alpha in murine stomach has been shown to induce gastric hypertrophy similar to MD. It can be hypothesized that increased expression of TGF-alpha may occur in the gastric mucosa in patients with UC and may lead to MD. We report the ninth case of MD associated with UC. The role of TGF-alpha and treatment with cetuximab are discussed.

KW - Cetuximab

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KW - Transforming growth factor-alpha

KW - Ulcerative colitis

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The association of ménétrier disease with ulcerative colitis: A case report with implications on the pathogenesis of ménétrier disease

Abstract

Keywords

ASJC Scopus subject areas

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