The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa

A prospective cohort study

Timothy J. Doyle, Wei Zheng, James R Cerhan, Ching Ping Hong, Thomas A. Sellers, Lawrence H. Kushi, Aaron R. Folsam

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Objectives: This study assessed the association of drinking water source and chlorination by-product exposure with cancer incidence. Methods: A cohort of 28 237 Iowa women reported their drinking water source. Exposure to chlorination by-products was determined from statewide water quality data. Results: In comparison with women who sed municipal groundwater sources, women with municipal surface water sources were at an increased risk of colon cancer and all cancers combined. A clear dose-response relation was observed between four categories of increasing chloroform levels in finished drinking water and the risk of colon cancer and all cancers combined. The relative risks were 1.00, 1.06, 1.39, and 1.68 for colon cancer and 1.00, 1.04, 1.24, and 1.25 for total cancers. No consistent association with either water source or chloroform concentration was observed for other cancer sites. Conclusions: These results suggest that exposure to chlorination by-products in drinking water is associated with increased risk of colon cancer.

Original languageEnglish (US)
Pages (from-to)1168-1176
Number of pages9
JournalAmerican Journal of Public Health
Volume87
Issue number7
StatePublished - Jul 1997
Externally publishedYes

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Halogenation
Drinking Water
Cohort Studies
Colonic Neoplasms
Prospective Studies
Incidence
Neoplasms
Chloroform
Water
Water Quality
Groundwater

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa : A prospective cohort study. / Doyle, Timothy J.; Zheng, Wei; Cerhan, James R; Hong, Ching Ping; Sellers, Thomas A.; Kushi, Lawrence H.; Folsam, Aaron R.

In: American Journal of Public Health, Vol. 87, No. 7, 07.1997, p. 1168-1176.

Research output: Contribution to journalArticle

Doyle, Timothy J. ; Zheng, Wei ; Cerhan, James R ; Hong, Ching Ping ; Sellers, Thomas A. ; Kushi, Lawrence H. ; Folsam, Aaron R. / The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa : A prospective cohort study. In: American Journal of Public Health. 1997 ; Vol. 87, No. 7. pp. 1168-1176.
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AU - Sellers, Thomas A.

AU - Kushi, Lawrence H.

AU - Folsam, Aaron R.

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