Abstract
Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.
Original language | English (US) |
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Pages (from-to) | 861-864 |
Number of pages | 4 |
Journal | Human Immunology |
Volume | 79 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2018 |
Keywords
- Allogeneic
- Donor Specific Antibody
- Graft failure
- Hematopoietic cell transplantation
- Human Leukocyte Antigen
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology