The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation

Mehrdad Hefazi, William Hogan, Laurie L. Wakefield, Manish J. Gandhi

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2 Scopus citations

Abstract

Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Jan 1 2018

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Keywords

  • Allogeneic
  • Donor Specific Antibody
  • Graft failure
  • Hematopoietic cell transplantation
  • Human Leukocyte Antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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