The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation

Mehrdad Hefazi, William Hogan, Laurie L. Wakefield, Manish J. Gandhi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.

Original languageEnglish (US)
JournalHuman Immunology
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Cell Transplantation
Antibody Formation
Tissue Donors
Transplants
Antibodies
Unrelated Donors
Pancytopenia
Homologous Transplantation
Anti-Idiotypic Antibodies
HLA-DPB1 antigen

Keywords

  • Allogeneic
  • Donor Specific Antibody
  • Graft failure
  • Hematopoietic cell transplantation
  • Human Leukocyte Antigen

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation. / Hefazi, Mehrdad; Hogan, William; Wakefield, Laurie L.; Gandhi, Manish J.

In: Human Immunology, 01.01.2018.

Research output: Contribution to journalArticle

@article{3f99aed2ac5d4a57be912adab750b14e,
title = "The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation",
abstract = "Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.",
keywords = "Allogeneic, Donor Specific Antibody, Graft failure, Hematopoietic cell transplantation, Human Leukocyte Antigen",
author = "Mehrdad Hefazi and William Hogan and Wakefield, {Laurie L.} and Gandhi, {Manish J.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.humimm.2018.08.009",
language = "English (US)",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - The association of de novo anti-HLA-DPB1 donor-specific antibody formation and primary graft failure after allogeneic hematopoietic cell transplantation

AU - Hefazi, Mehrdad

AU - Hogan, William

AU - Wakefield, Laurie L.

AU - Gandhi, Manish J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.

AB - Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remains unknown. Here, we present the first reported case of graft failure associated with de novo anti-HLA-DPB1 DSA after a 10/10 matched unrelated donor HCT. Based on this observation, testing for DSA should be considered in case of unexplained pancytopenia after allogeneic transplantation, especially after reduced intensity conditioning.

KW - Allogeneic

KW - Donor Specific Antibody

KW - Graft failure

KW - Hematopoietic cell transplantation

KW - Human Leukocyte Antigen

UR - http://www.scopus.com/inward/record.url?scp=85054316219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054316219&partnerID=8YFLogxK

U2 - 10.1016/j.humimm.2018.08.009

DO - 10.1016/j.humimm.2018.08.009

M3 - Article

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

ER -