The association between pressure ulcers and endothelial dysfunction in a cohort of community elderly

Paul Takahashi, Anupam Chandra, Casey Caldwell, Stephen Cha, Paul Targonski

Research output: Contribution to journalArticle

Abstract

Vascular disease is a known risk factor for pressure ulcer development, but the underlying mechanisms of this association are less established. The authors evaluated the relationship between endothelial function (EF) and history of pressure ulcers in a nested case-control study of community-dwelling elderly, 60 years and older. Endothelial function was measured using peripheral arterial tonometry, and persons with a history of pressure ulcers in the past 5 years (n ≤ 7) were matched 2:1 by age and gender to controls with no history of pressure ulcers (n ≤ 14). Overall endothelial function was significantly worse in persons with pressure ulcers compared to controls (1.32 versus 1.76, respectively; P ≤ 0.04), and the prevalence of endothelial dysfunction was higher among cases than controls as well (100% versus 43%, respectively; P ≤ 0.04). Other vascular risk factors were similar in both groups. Endothelial dysfunction appears to be associated with pressure ulcer history and may reflect an underlying vascular etiology through which ulcer risk is mediated.

Original languageEnglish (US)
Pages (from-to)290-291
Number of pages2
JournalWounds
Volume20
Issue number11
StatePublished - Nov 1 2008

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Fingerprint Dive into the research topics of 'The association between pressure ulcers and endothelial dysfunction in a cohort of community elderly'. Together they form a unique fingerprint.

  • Cite this

    Takahashi, P., Chandra, A., Caldwell, C., Cha, S., & Targonski, P. (2008). The association between pressure ulcers and endothelial dysfunction in a cohort of community elderly. Wounds, 20(11), 290-291.