Abstract
We retrospectively investigated the association between platelet autoantibody specificity and response to intravenous immunoglobulin G (IVIG) in 17 patients with immune thrombocytopenia (ITP). Platelet-associated antibodies against glycoprotein (GP) IIb/IIIa, GPIb/LX, and GPIa/IIa were detected in 13, 10, and 8 patients, respectively. A response occurred in 7 of 7 patients without anti-GPIb/IX, but in only 3 of 10 patients with anti-GPIb/IX (p<0.01). There was no difference in the response rates in patients with or without anti-GPIIb/IIIa or anti-GPIa/IIa. We conclude that ITP patients with anti-GPIb/IX may be less responsive to IVIG.
Original language | English (US) |
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Pages (from-to) | 283-284 |
Number of pages | 2 |
Journal | Haematologica |
Volume | 92 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- Immune thrombocytopenia
- Intravenous immunoglobulin
- Platelet autoantibody specificity
ASJC Scopus subject areas
- Hematology