The association between platelet autoantibody specificity and response to intravenous immunoglobulin G in the treatment of patients with immune thrombocytopenia

Ronald S. Go, Kaye L. Johnston, Kent C. Bruden

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

We retrospectively investigated the association between platelet autoantibody specificity and response to intravenous immunoglobulin G (IVIG) in 17 patients with immune thrombocytopenia (ITP). Platelet-associated antibodies against glycoprotein (GP) IIb/IIIa, GPIb/LX, and GPIa/IIa were detected in 13, 10, and 8 patients, respectively. A response occurred in 7 of 7 patients without anti-GPIb/IX, but in only 3 of 10 patients with anti-GPIb/IX (p<0.01). There was no difference in the response rates in patients with or without anti-GPIIb/IIIa or anti-GPIa/IIa. We conclude that ITP patients with anti-GPIb/IX may be less responsive to IVIG.

Original languageEnglish (US)
Pages (from-to)283-284
Number of pages2
JournalHaematologica
Volume92
Issue number2
DOIs
StatePublished - Feb 1 2007

Keywords

  • Immune thrombocytopenia
  • Intravenous immunoglobulin
  • Platelet autoantibody specificity

ASJC Scopus subject areas

  • Hematology

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