The association between HLA class I alleles and measles vaccine-induced antibody response: Evidence of a significant association

Gregory A. Poland, Robert M. Jacobson, Daniel J Schaid, S. Breanndan Moore, Steven J. Jacobsen

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

While the Moraten strain measles vaccine is an excellent, safe, and immunogenic vaccine, vaccine failure occurs, presumably when an individual develops an inadequate immune response. In this study, we examined the association of HLA class I genes and measles vaccine-induced antibody levels. We found that the allele distribution of HLA-B alleles differed between non- responders and hyper-responders (p = 0.002). Several class I alleles were associated with non-response (HLA-B13, -B44, and -C5); whereas several other alleles were associated with hyper-response (HLA-B7 and -B51). In addition, non-responders were more likely to be HLA-B homozygous than normal responders (odds ratio 2.1), and more likely to be homozygous than hyper-responders (odds ratio 3. 7, p = 0.031 Mantel-Haenzel for trend). Finally, we found evidence of an allele dose-response phenomenon for HLA-B7. We conclude that there are important associations between class I HLA genes and measles antibody levels following immunization.

Original languageEnglish (US)
Pages (from-to)1869-1871
Number of pages3
JournalVaccine
Volume16
Issue number19
DOIs
StatePublished - Nov 1998

Fingerprint

Measles Vaccine
Antibody Formation
Alleles
vaccines
alleles
antibodies
HLA-B7 Antigen
MHC Class I Genes
HLA-B Antigens
odds ratio
HLA-B13 Antigen
HLA-B44 Antigen
HLA-B51 Antigen
Vaccines
Odds Ratio
Antibodies
Measles
dose response
Immunization
immunization

Keywords

  • Antibody response
  • Class I human leucocyte antigen
  • Measles

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

The association between HLA class I alleles and measles vaccine-induced antibody response : Evidence of a significant association. / Poland, Gregory A.; Jacobson, Robert M.; Schaid, Daniel J; Moore, S. Breanndan; Jacobsen, Steven J.

In: Vaccine, Vol. 16, No. 19, 11.1998, p. 1869-1871.

Research output: Contribution to journalArticle

Poland, Gregory A. ; Jacobson, Robert M. ; Schaid, Daniel J ; Moore, S. Breanndan ; Jacobsen, Steven J. / The association between HLA class I alleles and measles vaccine-induced antibody response : Evidence of a significant association. In: Vaccine. 1998 ; Vol. 16, No. 19. pp. 1869-1871.
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