TY - JOUR
T1 - The association between HLA class I alleles and measles vaccine-induced antibody response
T2 - Evidence of a significant association
AU - Poland, Gregory A.
AU - Jacobson, Robert M.
AU - Schaid, Daniel
AU - Moore, S. Breanndan
AU - Jacobsen, Steven J.
N1 - Funding Information:
These studies were supported by funds from the Public Health Service: A14.5249,M O1 00585, 2AI 33144,a nd AR30582.Wew ish to thank Steve DeGoey, and Cindy Kroning of the Mayo Tissue Typing Laboratory for their assistancei n performing the class I typing. Invaluablea ssistancefr om Shelly Roberts, RN, Delena Weiss, LPN, and Lori Crandall, LPN is acknowledged in the recruitment of the subjects studiedi n this work. Finally we wish to thank the many parentsa nd children who made this study possibleb y their participation.
PY - 1998/11
Y1 - 1998/11
N2 - While the Moraten strain measles vaccine is an excellent, safe, and immunogenic vaccine, vaccine failure occurs, presumably when an individual develops an inadequate immune response. In this study, we examined the association of HLA class I genes and measles vaccine-induced antibody levels. We found that the allele distribution of HLA-B alleles differed between non- responders and hyper-responders (p = 0.002). Several class I alleles were associated with non-response (HLA-B13, -B44, and -C5); whereas several other alleles were associated with hyper-response (HLA-B7 and -B51). In addition, non-responders were more likely to be HLA-B homozygous than normal responders (odds ratio 2.1), and more likely to be homozygous than hyper-responders (odds ratio 3. 7, p = 0.031 Mantel-Haenzel for trend). Finally, we found evidence of an allele dose-response phenomenon for HLA-B7. We conclude that there are important associations between class I HLA genes and measles antibody levels following immunization.
AB - While the Moraten strain measles vaccine is an excellent, safe, and immunogenic vaccine, vaccine failure occurs, presumably when an individual develops an inadequate immune response. In this study, we examined the association of HLA class I genes and measles vaccine-induced antibody levels. We found that the allele distribution of HLA-B alleles differed between non- responders and hyper-responders (p = 0.002). Several class I alleles were associated with non-response (HLA-B13, -B44, and -C5); whereas several other alleles were associated with hyper-response (HLA-B7 and -B51). In addition, non-responders were more likely to be HLA-B homozygous than normal responders (odds ratio 2.1), and more likely to be homozygous than hyper-responders (odds ratio 3. 7, p = 0.031 Mantel-Haenzel for trend). Finally, we found evidence of an allele dose-response phenomenon for HLA-B7. We conclude that there are important associations between class I HLA genes and measles antibody levels following immunization.
KW - Antibody response
KW - Class I human leucocyte antigen
KW - Measles
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U2 - 10.1016/S0264-410X(98)00017-6
DO - 10.1016/S0264-410X(98)00017-6
M3 - Article
C2 - 9795394
AN - SCOPUS:0032210778
SN - 0264-410X
VL - 16
SP - 1869
EP - 1871
JO - Vaccine
JF - Vaccine
IS - 19
ER -