TY - JOUR
T1 - The association between early life and adult body mass index and physical activity with risk of non-Hodgkin lymphoma
T2 - Impact of gender
AU - Kelly, Jennifer L.
AU - Fredericksen, Zachary S.
AU - Liebow, Mark
AU - Shanafelt, Tait D.
AU - Thompson, Carrie A.
AU - Call, Timothy G.
AU - Habermann, Thomas M.
AU - Macon, William R.
AU - Wang, Alice H.
AU - Slager, Susan L.
AU - Cerhan, James R.
N1 - Funding Information:
The authors thank Sondra Buehler for her editorial assistance. This work was supported by awards from the National Institutes of Health, National Cancer Institute [ R01 CA92153 ; P50 CA97274 ]. Dr J.L.K. was supported by the National Institutes of Health , National Heart Lung and Blood Institute [ HL007152 ], National Cancer Institute [ P50 CA130805 ; K07 CA157580 ], and the Lymphoma Research Foundation Fellowship Program .
PY - 2012/12
Y1 - 2012/12
N2 - Purpose: To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL). Methods: We enrolled 950 newly diagnosed NHL patients and 1146 frequency-matched clinic-based controls. Height, weight, and PA (recent adult and at the age of 18 years) were self-reported. Odds ratios (ORs), 95% confidence intervals, and tests for trend were estimated using unconditional logistic regression adjusted for age, gender, and residence. Results: BMI at the age of 18 years was associated with an increased NHL risk (OR, 1.38 for highest vs. lowest quartile; p-trend = .0012), which on stratified analysis was specific to females (OR, 1.90; p-trend = .00025). There was no association of adult BMI with NHL risk. Higher PA in adulthood (OR, 1.03; p-trend = .85) or at the age of 18 years (OR, 0.88; 95% confidence interval, 0.72-1.07) was not associated with risk, but there was an inverse association for adult PA that was specific to females (OR, 0.71; p-trend = .039). Only BMI at the age of 18 years remained significantly associated with NHL risk when modeled together with PA in adulthood or at the age of 18 years. There was little evidence for heterogeneity in these results for the common NHL subtypes. Conclusions: Early adult BMI may be of greatest relevance to NHL risk, particularly in females.
AB - Purpose: To evaluate the association of body mass index (BMI) and physical activity (PA) during adulthood and at the age of 18 years with risk of non-Hodgkin lymphoma (NHL). Methods: We enrolled 950 newly diagnosed NHL patients and 1146 frequency-matched clinic-based controls. Height, weight, and PA (recent adult and at the age of 18 years) were self-reported. Odds ratios (ORs), 95% confidence intervals, and tests for trend were estimated using unconditional logistic regression adjusted for age, gender, and residence. Results: BMI at the age of 18 years was associated with an increased NHL risk (OR, 1.38 for highest vs. lowest quartile; p-trend = .0012), which on stratified analysis was specific to females (OR, 1.90; p-trend = .00025). There was no association of adult BMI with NHL risk. Higher PA in adulthood (OR, 1.03; p-trend = .85) or at the age of 18 years (OR, 0.88; 95% confidence interval, 0.72-1.07) was not associated with risk, but there was an inverse association for adult PA that was specific to females (OR, 0.71; p-trend = .039). Only BMI at the age of 18 years remained significantly associated with NHL risk when modeled together with PA in adulthood or at the age of 18 years. There was little evidence for heterogeneity in these results for the common NHL subtypes. Conclusions: Early adult BMI may be of greatest relevance to NHL risk, particularly in females.
KW - Body mass index
KW - Case-control studies
KW - Etiology
KW - Exercise
KW - Non-Hodgkin lymphoma
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U2 - 10.1016/j.annepidem.2012.10.002
DO - 10.1016/j.annepidem.2012.10.002
M3 - Article
C2 - 23146413
AN - SCOPUS:84870239683
SN - 1047-2797
VL - 22
SP - 855
EP - 862
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 12
ER -