The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Sanjay Dandamudi; Horng H. Chen

doi:10.1586/erc.12.31

The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Sanjay Dandamudi, Horng H. Chen

Research output: Contribution to journal › Review article

11 Scopus citations

Abstract

Nesiritide has been approved by the US FDA for the treatment of acute decompensated heart failure since 2001. Subsequently, two meta-analyses questioned its impact on mortality and association with worsening renal function. Therefore, the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial was designed to assess the safety and efficacy of nesiritide in acute decompensated heart failure based on clinically relevant outcomes. In this article, the important findings and lessons learned from this landmark study are reviewed and potential evolving roles for nesiritide and natriuretic peptides in the future of heart failure therapy are proposed.

Original language	English (US)
Pages (from-to)	557-563
Number of pages	7
Journal	Expert Review of Cardiovascular Therapy
Volume	10
Issue number	5
DOIs	https://doi.org/10.1586/erc.12.31
State	Published - May 1 2012

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Keywords

ASCEND-HF
heart failure
heart failure therapy
natriuretic peptides
nesiritide

ASJC Scopus subject areas

Internal Medicine
Cardiology and Cardiovascular Medicine

Cite this

Dandamudi, S., & Chen, H. H. (2012). The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure. Expert Review of Cardiovascular Therapy, 10(5), 557-563. https://doi.org/10.1586/erc.12.31

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Access to Document

10.1586/erc.12.31