The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Sanjay Dandamudi; Horng H. Chen

doi:10.1586/erc.12.31

The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Sanjay Dandamudi, Horng H. Chen

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Nesiritide has been approved by the US FDA for the treatment of acute decompensated heart failure since 2001. Subsequently, two meta-analyses questioned its impact on mortality and association with worsening renal function. Therefore, the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial was designed to assess the safety and efficacy of nesiritide in acute decompensated heart failure based on clinically relevant outcomes. In this article, the important findings and lessons learned from this landmark study are reviewed and potential evolving roles for nesiritide and natriuretic peptides in the future of heart failure therapy are proposed.

Original language	English (US)
Pages (from-to)	557-563
Number of pages	7
Journal	Expert Review of Cardiovascular Therapy
Volume	10
Issue number	5
DOIs	https://doi.org/10.1586/erc.12.31
State	Published - May 2012

Keywords

ASCEND-HF
heart failure
heart failure therapy
natriuretic peptides
nesiritide

ASJC Scopus subject areas

Internal Medicine
Cardiology and Cardiovascular Medicine

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10.1586/erc.12.31

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title = "The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure",

abstract = "Nesiritide has been approved by the US FDA for the treatment of acute decompensated heart failure since 2001. Subsequently, two meta-analyses questioned its impact on mortality and association with worsening renal function. Therefore, the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial was designed to assess the safety and efficacy of nesiritide in acute decompensated heart failure based on clinically relevant outcomes. In this article, the important findings and lessons learned from this landmark study are reviewed and potential evolving roles for nesiritide and natriuretic peptides in the future of heart failure therapy are proposed.",

keywords = "ASCEND-HF, heart failure, heart failure therapy, natriuretic peptides, nesiritide",

author = "Sanjay Dandamudi and Chen, {Horng H.}",

note = "Funding Information: Mayo Clinic and HH Chen have patented and licensed designer natriuretic peptides other than B-type natriuretic peptide. HH Chen has received a research grant from Scios Inc. HH Chen has a consulting agreement with Anexon Inc. and has received royalties form Niles Therapeutics, Inc. and UpToDate, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2012",

month = may,

doi = "10.1586/erc.12.31",

language = "English (US)",

volume = "10",

pages = "557--563",

journal = "Expert Review of Cardiovascular Therapy",

issn = "1477-9072",

publisher = "Expert Reviews Ltd.",

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T2 - An acute study of clinical effectiveness of nesiritide and decompensated heart failure

AU - Dandamudi, Sanjay

AU - Chen, Horng H.

N1 - Funding Information: Mayo Clinic and HH Chen have patented and licensed designer natriuretic peptides other than B-type natriuretic peptide. HH Chen has received a research grant from Scios Inc. HH Chen has a consulting agreement with Anexon Inc. and has received royalties form Niles Therapeutics, Inc. and UpToDate, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2012/5

Y1 - 2012/5

N2 - Nesiritide has been approved by the US FDA for the treatment of acute decompensated heart failure since 2001. Subsequently, two meta-analyses questioned its impact on mortality and association with worsening renal function. Therefore, the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial was designed to assess the safety and efficacy of nesiritide in acute decompensated heart failure based on clinically relevant outcomes. In this article, the important findings and lessons learned from this landmark study are reviewed and potential evolving roles for nesiritide and natriuretic peptides in the future of heart failure therapy are proposed.

AB - Nesiritide has been approved by the US FDA for the treatment of acute decompensated heart failure since 2001. Subsequently, two meta-analyses questioned its impact on mortality and association with worsening renal function. Therefore, the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure trial was designed to assess the safety and efficacy of nesiritide in acute decompensated heart failure based on clinically relevant outcomes. In this article, the important findings and lessons learned from this landmark study are reviewed and potential evolving roles for nesiritide and natriuretic peptides in the future of heart failure therapy are proposed.

KW - ASCEND-HF

KW - heart failure

KW - heart failure therapy

KW - natriuretic peptides

KW - nesiritide

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U2 - 10.1586/erc.12.31

DO - 10.1586/erc.12.31

M3 - Review article

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VL - 10

SP - 557

EP - 563

JO - Expert Review of Cardiovascular Therapy

JF - Expert Review of Cardiovascular Therapy

SN - 1477-9072

IS - 5

ER -

The ASCEND-HF trial: An acute study of clinical effectiveness of nesiritide and decompensated heart failure

Abstract

Keywords

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