The art of managing conversions between antiepileptic drugs: Maximizing patient tolerability and quality of life

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AEDs on quality of life in epilepsy patients, then reviews several important patient-related factors such as age, gender, medical and psychiatric co-morbidities, and co-medications that must be considered when selecting AEDs and ensuring tolerable and safe AED conversions. Practical strategies for transitional polytherapy AED conversion are then considered in different commonly encountered clinical scenarios in newly diagnosed and refractory epilepsy care, including inadequate seizure control, intolerable adverse effects, or idiosyncratic safety hazards. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life.

Original languageEnglish (US)
Pages (from-to)2956-2969
Number of pages14
JournalPharmaceuticals
Volume3
Issue number9
DOIs
StatePublished - 2010

Fingerprint

Anticonvulsants
Quality of Life
Pharmaceutical Preparations
Epilepsy
Physiologic Monitoring
Psychiatry
Patient Care
Seizures
Morbidity
Safety
Drug Therapy

Keywords

  • Antiepileptic drugs
  • Conversion
  • Epilepsy
  • Monotherapy
  • Polytherapy
  • Quality of life

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

The art of managing conversions between antiepileptic drugs : Maximizing patient tolerability and quality of life. / St Louis, Erik K.

In: Pharmaceuticals, Vol. 3, No. 9, 2010, p. 2956-2969.

Research output: Contribution to journalArticle

@article{86cbb483dd3142de8950c1bfafbeb8ec,
title = "The art of managing conversions between antiepileptic drugs: Maximizing patient tolerability and quality of life",
abstract = "Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AEDs on quality of life in epilepsy patients, then reviews several important patient-related factors such as age, gender, medical and psychiatric co-morbidities, and co-medications that must be considered when selecting AEDs and ensuring tolerable and safe AED conversions. Practical strategies for transitional polytherapy AED conversion are then considered in different commonly encountered clinical scenarios in newly diagnosed and refractory epilepsy care, including inadequate seizure control, intolerable adverse effects, or idiosyncratic safety hazards. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life.",
keywords = "Antiepileptic drugs, Conversion, Epilepsy, Monotherapy, Polytherapy, Quality of life",
author = "{St Louis}, {Erik K}",
year = "2010",
doi = "10.3390/ph3092956",
language = "English (US)",
volume = "3",
pages = "2956--2969",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

TY - JOUR

T1 - The art of managing conversions between antiepileptic drugs

T2 - Maximizing patient tolerability and quality of life

AU - St Louis, Erik K

PY - 2010

Y1 - 2010

N2 - Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AEDs on quality of life in epilepsy patients, then reviews several important patient-related factors such as age, gender, medical and psychiatric co-morbidities, and co-medications that must be considered when selecting AEDs and ensuring tolerable and safe AED conversions. Practical strategies for transitional polytherapy AED conversion are then considered in different commonly encountered clinical scenarios in newly diagnosed and refractory epilepsy care, including inadequate seizure control, intolerable adverse effects, or idiosyncratic safety hazards. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life.

AB - Conversion between anti-epilectic drugs (AEDs) is frequently necessary in epilepsy care, exposing patients to a risk of incurring adverse effects and reduced quality of life. Little practical guidance is available to practitioners to guide conversions between AED monotherapies, or in adding a new adjunctive AED into a polytherapy regimen. This article reviews the impact of adverse effects of AEDs on quality of life in epilepsy patients, then reviews several important patient-related factors such as age, gender, medical and psychiatric co-morbidities, and co-medications that must be considered when selecting AEDs and ensuring tolerable and safe AED conversions. Practical strategies for transitional polytherapy AED conversion are then considered in different commonly encountered clinical scenarios in newly diagnosed and refractory epilepsy care, including inadequate seizure control, intolerable adverse effects, or idiosyncratic safety hazards. Successful conversion between AEDs requires regular monitoring for patient-reported adverse effects and appropriately reactive adjustment of AED therapy to maximize patient quality of life.

KW - Antiepileptic drugs

KW - Conversion

KW - Epilepsy

KW - Monotherapy

KW - Polytherapy

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=77957284607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957284607&partnerID=8YFLogxK

U2 - 10.3390/ph3092956

DO - 10.3390/ph3092956

M3 - Article

AN - SCOPUS:77957284607

VL - 3

SP - 2956

EP - 2969

JO - Pharmaceuticals

JF - Pharmaceuticals

SN - 1424-8247

IS - 9

ER -