The antiviral dynamin family member, MxA, tubulates lipids and localizes to the smooth endoplasmic reticulum

Molly A. Accola, Bing Huang, Azzah Al Masri, Mark A. McNiven

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Mx proteins are induced by type I interferon and inhibit a broad range of viruses by undefined mechanisms. They are included within the dynamin family of large GTPases, which are involved in vesicle trafficking and share common biophysical features. These properties include the propensity to self-assemble, an affinity for lipids, and the ability to tubulate membranes. In this report we establish that human MxA, despite sharing only 30% homology with conventional dynamin, possesses many of these properties. We demonstrate for the first time that MxA self-assembles into rings that tubulate lipids in vitro, and associates with a specific membrane compartment in cells, the smooth endoplasmic reticulum.

Original languageEnglish (US)
Pages (from-to)21829-21835
Number of pages7
JournalJournal of Biological Chemistry
Volume277
Issue number24
DOIs
StatePublished - Jun 14 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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