The androgen receptor: A potential target for therapy of prostate cancer

A. F. Santos, H. Huang, D. J. Tindall

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide responsive gene products for differentiation and growth, but under abnormal conditions it contributes to the development of prostate cancer. The goal of this review is to elucidate the molecular functions of the androgen receptor and its role in prostate cancer. Initially the function of the androgen receptor will be described. Next, the clinical diagnosis, epidemiological impact, and treatments of androgen-dependent and -independent prostate cancer will be discussed. Finally we will examine how the mechanism of androgen action has played a role in the translation of new therapies and how this may influence future treatment modalities of prostate cancer.

Original languageEnglish (US)
Pages (from-to)79-85
Number of pages7
JournalSteroids
Volume69
Issue number2
DOIs
StatePublished - Feb 1 2004

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Keywords

  • Androgen
  • Androgen receptor
  • Hormone-refractory prostate cancer
  • Prostate cancer
  • Steroid

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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