The androgen receptor: A potential target for therapy of prostate cancer

A. F. Santos; H. Huang; D. J. Tindall

doi:10.1016/j.steroids.2003.10.005

The androgen receptor: A potential target for therapy of prostate cancer

A. F. Santos, H. Huang, D. J. Tindall

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide responsive gene products for differentiation and growth, but under abnormal conditions it contributes to the development of prostate cancer. The goal of this review is to elucidate the molecular functions of the androgen receptor and its role in prostate cancer. Initially the function of the androgen receptor will be described. Next, the clinical diagnosis, epidemiological impact, and treatments of androgen-dependent and -independent prostate cancer will be discussed. Finally we will examine how the mechanism of androgen action has played a role in the translation of new therapies and how this may influence future treatment modalities of prostate cancer.

Original language	English (US)
Pages (from-to)	79-85
Number of pages	7
Journal	Steroids
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/j.steroids.2003.10.005
State	Published - Feb 2004

Keywords

Androgen
Androgen receptor
Hormone-refractory prostate cancer
Prostate cancer
Steroid

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/j.steroids.2003.10.005

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abstract = "The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide responsive gene products for differentiation and growth, but under abnormal conditions it contributes to the development of prostate cancer. The goal of this review is to elucidate the molecular functions of the androgen receptor and its role in prostate cancer. Initially the function of the androgen receptor will be described. Next, the clinical diagnosis, epidemiological impact, and treatments of androgen-dependent and -independent prostate cancer will be discussed. Finally we will examine how the mechanism of androgen action has played a role in the translation of new therapies and how this may influence future treatment modalities of prostate cancer.",

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AB - The androgen receptor plays a pivotal role in the prostate. Its primary function is to provide responsive gene products for differentiation and growth, but under abnormal conditions it contributes to the development of prostate cancer. The goal of this review is to elucidate the molecular functions of the androgen receptor and its role in prostate cancer. Initially the function of the androgen receptor will be described. Next, the clinical diagnosis, epidemiological impact, and treatments of androgen-dependent and -independent prostate cancer will be discussed. Finally we will examine how the mechanism of androgen action has played a role in the translation of new therapies and how this may influence future treatment modalities of prostate cancer.

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KW - Hormone-refractory prostate cancer

KW - Prostate cancer

KW - Steroid

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The androgen receptor: A potential target for therapy of prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

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