The analgesic domain of IL-2

Yan Asmann, Li Li, Jianfeng Liu, Zhiyong Wang, Chunlei Jiang, Xinyuan Liu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Human recombinant interleukin-2 (IL-2) has been showed to exert an analgesic effect and some experiments suggested that opioid receptors were involved. Because the aromatic residues at the N-termini of opioid peptides are crucial for their binding to the opioid receptors, all nine aromatic residues in IL-2 were mutated by site-directed mutagenesis and both the analgesic activity and the immune activity of the wild-type and mutated IL-2 were tested. The result indicated that there exists a putative analgesic function domain in IL-2, in which Phe44, Tyr45, Tyr107, and Phe117 were essential. These four residues are located close together at the tertiary structure level of IL-2.

Original languageEnglish (US)
Pages (from-to)542-545
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume230
Issue number3
DOIs
StatePublished - Jan 23 1997
Externally publishedYes

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Interleukin-2
Analgesics
Opioid Receptors
Mutagenesis
Opioid Peptides
Site-Directed Mutagenesis
Experiments

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

The analgesic domain of IL-2. / Asmann, Yan; Li, Li; Liu, Jianfeng; Wang, Zhiyong; Jiang, Chunlei; Liu, Xinyuan.

In: Biochemical and Biophysical Research Communications, Vol. 230, No. 3, 23.01.1997, p. 542-545.

Research output: Contribution to journalArticle

Asmann, Y, Li, L, Liu, J, Wang, Z, Jiang, C & Liu, X 1997, 'The analgesic domain of IL-2', Biochemical and Biophysical Research Communications, vol. 230, no. 3, pp. 542-545. https://doi.org/10.1006/bbrc.1996.5961
Asmann, Yan ; Li, Li ; Liu, Jianfeng ; Wang, Zhiyong ; Jiang, Chunlei ; Liu, Xinyuan. / The analgesic domain of IL-2. In: Biochemical and Biophysical Research Communications. 1997 ; Vol. 230, No. 3. pp. 542-545.
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