@article{96c45cf0657c4021aa437554c8921cf5,
title = "The Alzheimer's disease neuroimaging initiative",
abstract = "With increasing life expectancy in developed countries, the incidence of Alzheimer's disease (AD) and its socioeconomic impact are growing. Increasing knowledge of the mechanisms of AD facilitates the development of treatment strategies aimed at slowing down or preventing neuronal death. AD treatment trials using clinical outcome measures require long observation times and large patient samples. There is increasing evidence that neuroimaging and cerebrospinal fluid and blood biomarkers may provide information that may reduce sample sizes and observation periods. The Alzheimer's Disease Neuroimaging Initiative will help identify clinical, neuroimaging, and biomarker outcome measures that provide the highest power for measurement of longitudinal changes and for prediction of transitions.",
author = "Mueller, {Susanne G.} and Weiner, {Michael W.} and Thal, {Leon J.} and Petersen, {Ronald C.} and Clifford Jack and William Jagust and Trojanowski, {John Q.} and Toga, {Arthur W.} and Laurel Beckett",
note = "Funding Information: The ADNI is funded by the National Institute on Aging and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes of Health (NIH), several pharmaceutical companies (Pfizer, Wyeth, Eli Lilly, Merck, GlaxoSmithKline, AstraZeneca, Novartis, Eisai, Elan, Forest Laboratories, Bristol Meyers Squibb), and foundations (Alzheimers Association, Institute for Study of Aging) in conjunction with the NIH Foundation ( Fig. 1 ). This initiative encompasses clinical sites in the United States and Canada and is to date the most comprehensive effort to identify neuroimaging measures and biomarkers associated with cognitive and functional changes in healthy elderly subjects and in subjects who have MCI and AD. The overall goals of the ADNI are: ",
year = "2005",
month = nov,
doi = "10.1016/j.nic.2005.09.008",
language = "English (US)",
volume = "15",
pages = "869--877",
journal = "Neuroimaging Clinics of North America",
issn = "1052-5149",
publisher = "W.B. Saunders Ltd",
number = "4",
}