The Akt/mTOR and mitogen-activated protein kinase pathways in lung cancer therapy

Vassiliki Papadimitrakopoulou, Alex A. Adjei

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Aberrant intracellular signaling resulting from mutations and oncogenic activation, as well as gene amplification of critical proteins involved in signal transduction pathways, are key features of lung cancer. Three important intracellular signaling proteins, the mammalian target of rapamycin, protein kinase B, and mitogen-activated protein kinase kinase have emerged as attractive targets for lung cancer therapy. We review current information on the therapeutic manipulation of these targets and describe early clinical data in lung cancer.

Original languageEnglish (US)
Pages (from-to)749-751
Number of pages3
JournalJournal of Thoracic Oncology
Volume1
Issue number7
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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