The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback

Johannes D. Veldhuis; Daniel M. Keenan; Peter Y. Liu; Ali Iranmanesh; Paul Y. Takahashi; Ajay X. Nehra

doi:10.1016/j.mce.2008.09.005

The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback

Johannes D. Veldhuis, Daniel M. Keenan, Peter Y. Liu, Ali Iranmanesh, Paul Y. Takahashi, Ajay X. Nehra

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E₂). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

Original language	English (US)
Pages (from-to)	14-22
Number of pages	9
Journal	Molecular and Cellular Endocrinology
Volume	299
Issue number	1
DOIs	https://doi.org/10.1016/j.mce.2008.09.005
State	Published - Feb 5 2009

Keywords

Approximate entropy
Deconvolution
Gonadotropin
Mechanism
Pulses

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

Access to Document

10.1016/j.mce.2008.09.005

Cite this

@article{9edf947019b24f61aee45a3919e6547e,

title = "The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback",

abstract = "Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E2). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.",

keywords = "Approximate entropy, Deconvolution, Gonadotropin, Mechanism, Pulses",

author = "Veldhuis, {Johannes D.} and Keenan, {Daniel M.} and Liu, {Peter Y.} and Ali Iranmanesh and Takahashi, {Paul Y.} and Nehra, {Ajay X.}",

note = "Funding Information: We thank Kay Nevinger and Donna Scott for support of manuscript preparation; Ashley Bryant for data analysis and graphics; the Mayo Immunochemical Laboratory for assay assistance; and the Mayo research nursing staff for implementing the protocol. Supported in part via the Center for Translational Science Activities (CTSA) Grant Number 1 UL 1 RR024150, RR019991 from the National Center for Research Resources (Rockville, MD), and AG23133, AG029362, DK072095 and DK063609 from the National Institutes of Health (Bethesda, MD).",

year = "2009",

month = feb,

day = "5",

doi = "10.1016/j.mce.2008.09.005",

language = "English (US)",

volume = "299",

pages = "14--22",

journal = "Molecular and Cellular Endocrinology",

issn = "0303-7207",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - The aging male hypothalamic-pituitary-gonadal axis

T2 - Pulsatility and feedback

AU - Veldhuis, Johannes D.

AU - Keenan, Daniel M.

AU - Liu, Peter Y.

AU - Iranmanesh, Ali

AU - Takahashi, Paul Y.

AU - Nehra, Ajay X.

N1 - Funding Information: We thank Kay Nevinger and Donna Scott for support of manuscript preparation; Ashley Bryant for data analysis and graphics; the Mayo Immunochemical Laboratory for assay assistance; and the Mayo research nursing staff for implementing the protocol. Supported in part via the Center for Translational Science Activities (CTSA) Grant Number 1 UL 1 RR024150, RR019991 from the National Center for Research Resources (Rockville, MD), and AG23133, AG029362, DK072095 and DK063609 from the National Institutes of Health (Bethesda, MD).

PY - 2009/2/5

Y1 - 2009/2/5

N2 - Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E2). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

AB - Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E2). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

KW - Approximate entropy

KW - Deconvolution

KW - Gonadotropin

KW - Mechanism

KW - Pulses

UR - http://www.scopus.com/inward/record.url?scp=58349087177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58349087177&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2008.09.005

DO - 10.1016/j.mce.2008.09.005

M3 - Article

C2 - 18838102

AN - SCOPUS:58349087177

SN - 0303-7207

VL - 299

SP - 14

EP - 22

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

IS - 1

ER -

The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this