The aging male hypothalamic-pituitary-gonadal axis: Pulsatility and feedback

Johannes D Veldhuis, Daniel M. Keenan, Peter Y. Liu, Ali Iranmanesh, Paul Y Takahashi, Ajay X. Nehra

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E2). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as assessed by recent objective ensemble models of the axis as a whole.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalMolecular and Cellular Endocrinology
Volume299
Issue number1
DOIs
StatePublished - Feb 5 2009

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Internal-External Control
Luteinizing Hormone
Gonadotropin-Releasing Hormone
Testosterone
Estradiol
Aging of materials
Feedback

Keywords

  • Approximate entropy
  • Deconvolution
  • Gonadotropin
  • Mechanism
  • Pulses

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

The aging male hypothalamic-pituitary-gonadal axis : Pulsatility and feedback. / Veldhuis, Johannes D; Keenan, Daniel M.; Liu, Peter Y.; Iranmanesh, Ali; Takahashi, Paul Y; Nehra, Ajay X.

In: Molecular and Cellular Endocrinology, Vol. 299, No. 1, 05.02.2009, p. 14-22.

Research output: Contribution to journalArticle

Veldhuis, Johannes D ; Keenan, Daniel M. ; Liu, Peter Y. ; Iranmanesh, Ali ; Takahashi, Paul Y ; Nehra, Ajay X. / The aging male hypothalamic-pituitary-gonadal axis : Pulsatility and feedback. In: Molecular and Cellular Endocrinology. 2009 ; Vol. 299, No. 1. pp. 14-22.
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