TY - JOUR
T1 - The adrenoleukomyeloneuropathy complex
T2 - Expression in four generations
AU - O’Neill, B. P.
AU - Marmion, L. C.
AU - Feringa, E. R.
PY - 1981/2
Y1 - 1981/2
N2 - Varying combinations of leukodystrophy, myeloneuropathy, peripheral neuropathy, and primary Addison disease were identified in 14 members of four generations of a kindred of 49 persons. Of these, 26 persons from three generations were evaluated clinically. We propose that adrenoleukomyeloneuropathy (ALMN) is a rare, progressive, presumably biochemical disorder of uncertain inheritance. ALMN is expressed clinically by dysfunction of the central nervous system, peripheral nervous system, and endocrine system. We stress that suspicion of this disorder be high in evaluating uncertain neurologic disorders, and that identification of one manifestation of this complex should alert the clinician to the possibility of a different expression of the same complex in other family members.
AB - Varying combinations of leukodystrophy, myeloneuropathy, peripheral neuropathy, and primary Addison disease were identified in 14 members of four generations of a kindred of 49 persons. Of these, 26 persons from three generations were evaluated clinically. We propose that adrenoleukomyeloneuropathy (ALMN) is a rare, progressive, presumably biochemical disorder of uncertain inheritance. ALMN is expressed clinically by dysfunction of the central nervous system, peripheral nervous system, and endocrine system. We stress that suspicion of this disorder be high in evaluating uncertain neurologic disorders, and that identification of one manifestation of this complex should alert the clinician to the possibility of a different expression of the same complex in other family members.
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U2 - 10.1212/wnl.31.2.151
DO - 10.1212/wnl.31.2.151
M3 - Article
C2 - 6258103
AN - SCOPUS:0019492968
SN - 0028-3878
VL - 31
SP - 151
EP - 156
JO - Neurology
JF - Neurology
IS - 2
ER -