The adrenoleukomyeloneuropathy complex: Expression in four generations

Brian Patrick O'Neill, L. C. Marmion, E. R. Feringa

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Abstract

Varying combinations of leukodystrophy, myeloneuropathy, peripheral neuropathy, and primary Addison disease were identified in 14 members of four generations of a kindred of 49 persons. Of these, 26 persons from three generations were evaluated clinically. The authors propose that adrenoleukomyeloneuropathy (ALMN) is a rare, progressive, presumably biochemical disorder of uncertain inheritance. ALMN is expressed clinically by dysfunction of the central nervous system, and endocrine system. The authors stress that suspicion of this disorder be high in evaluating uncertain neurologic disorders, and that identification of one manifestation of this complex should alert the clinician to the possibility of a different expression of the same complex in other family members.

Original languageEnglish (US)
Pages (from-to)151-156
Number of pages6
JournalNeurology
Volume31
Issue number2
StatePublished - 1981

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Addison Disease
Endocrine System
Peripheral Nervous System Diseases
Nervous System Diseases
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

O'Neill, B. P., Marmion, L. C., & Feringa, E. R. (1981). The adrenoleukomyeloneuropathy complex: Expression in four generations. Neurology, 31(2), 151-156.

The adrenoleukomyeloneuropathy complex : Expression in four generations. / O'Neill, Brian Patrick; Marmion, L. C.; Feringa, E. R.

In: Neurology, Vol. 31, No. 2, 1981, p. 151-156.

Research output: Contribution to journalArticle

O'Neill, BP, Marmion, LC & Feringa, ER 1981, 'The adrenoleukomyeloneuropathy complex: Expression in four generations', Neurology, vol. 31, no. 2, pp. 151-156.
O'Neill, Brian Patrick ; Marmion, L. C. ; Feringa, E. R. / The adrenoleukomyeloneuropathy complex : Expression in four generations. In: Neurology. 1981 ; Vol. 31, No. 2. pp. 151-156.
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