Abstract
Using glass microelectrode technique and whole-cell patch clamp technique, we studied the action and mechanism of endothelin-1 (ET-1) inducing early after depolarizations (EADs) in guinea pig ventricular myocytes. The results suggested that the prolongation of APD50 was induced and EADs was demonstrated with 50 nmol/L ET-1 perfusion. These were resulted from the enhancement of L-Ica influx and a left shift on the steady-state activation curve with dose-dependence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 381-383+399 |
| Journal | Chinese Journal of Cardiology |
| Volume | 23 |
| Issue number | 5 |
| State | Published - 1995 |
ASJC Scopus subject areas
- General Medicine