The action and mechanism of trigger activity of endothelin-1 on ventricular myocytes of guinea pig

Y. Huang, T. Lu, W. Jiang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Using glass microelectrode technique and whole-cell patch clamp technique, we studied the action and mechanism of endothelin-1 (ET-1) inducing early after depolarizations (EADs) in guinea pig ventricular myocytes. The results suggested that the prolongation of APD50 was induced and EADs was demonstrated with 50 nmol/L ET-1 perfusion. These were resulted from the enhancement of L-Ica influx and a left shift on the steady-state activation curve with dose-dependence.

Original languageEnglish (US)
Pages (from-to)381-383+399
JournalChinese Journal of Cardiology
Volume23
Issue number5
StatePublished - Dec 1 1995

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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