The absolute monocyte count is associated with overall survival in patients newly diagnosed with follicular lymphoma

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Abstract

Follicular lymphoma is characterized by a highly variable clinical course ranging from early transformation and disease-related mortality to prolonged periods of disease stability or even spontaneous remissions. This clinical heterogeneity is likely explained by differences in the tumor microenvironment, including variable infiltration by monocyte-derived cells. Therefore, we examined the absolute monocyte count obtained from a standard complete blood count with differential at the time of diagnosis as a prognostic factor in a cohort of patients with follicular lymphoma (n = 355) treated at a single institution between 1998 and 2007. We found that the absolute monocyte count at diagnosis is associated with overall survival, independent of the Follicular Lymphoma International Prognostic Index (FLIPI). Furthermore, the absolute monocyte count improved the ability to identify high-risk patients when used in conjunction with the FLIPI. These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalLeukemia and Lymphoma
Volume53
Issue number4
DOIs
StatePublished - Apr 2012

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Follicular Lymphoma
Monocytes
Survival
Spontaneous Remission
Tumor Microenvironment
Blood Cell Count
Myeloid Cells
Mortality

Keywords

  • FLIPI
  • Follicular lymphoma
  • Monocyte
  • Prognosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "The absolute monocyte count is associated with overall survival in patients newly diagnosed with follicular lymphoma",
abstract = "Follicular lymphoma is characterized by a highly variable clinical course ranging from early transformation and disease-related mortality to prolonged periods of disease stability or even spontaneous remissions. This clinical heterogeneity is likely explained by differences in the tumor microenvironment, including variable infiltration by monocyte-derived cells. Therefore, we examined the absolute monocyte count obtained from a standard complete blood count with differential at the time of diagnosis as a prognostic factor in a cohort of patients with follicular lymphoma (n = 355) treated at a single institution between 1998 and 2007. We found that the absolute monocyte count at diagnosis is associated with overall survival, independent of the Follicular Lymphoma International Prognostic Index (FLIPI). Furthermore, the absolute monocyte count improved the ability to identify high-risk patients when used in conjunction with the FLIPI. These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology.",
keywords = "FLIPI, Follicular lymphoma, Monocyte, Prognosis",
author = "Wilcox, {Ryan A.} and Kay Ristow and Habermann, {Thomas Matthew} and Inwards, {David J.} and Ivana Micallef and Johnston, {Patrick Bruce} and Colgan, {Joseph P.} and Nowakowski, {Grzegorz S} and Ansell, {Stephen Maxted} and Witzig, {Thomas Elmer} and Markovic, {Svetomir Nenad} and Luis Porrata",
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AU - Wilcox, Ryan A.

AU - Ristow, Kay

AU - Habermann, Thomas Matthew

AU - Inwards, David J.

AU - Micallef, Ivana

AU - Johnston, Patrick Bruce

AU - Colgan, Joseph P.

AU - Nowakowski, Grzegorz S

AU - Ansell, Stephen Maxted

AU - Witzig, Thomas Elmer

AU - Markovic, Svetomir Nenad

AU - Porrata, Luis

PY - 2012/4

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N2 - Follicular lymphoma is characterized by a highly variable clinical course ranging from early transformation and disease-related mortality to prolonged periods of disease stability or even spontaneous remissions. This clinical heterogeneity is likely explained by differences in the tumor microenvironment, including variable infiltration by monocyte-derived cells. Therefore, we examined the absolute monocyte count obtained from a standard complete blood count with differential at the time of diagnosis as a prognostic factor in a cohort of patients with follicular lymphoma (n = 355) treated at a single institution between 1998 and 2007. We found that the absolute monocyte count at diagnosis is associated with overall survival, independent of the Follicular Lymphoma International Prognostic Index (FLIPI). Furthermore, the absolute monocyte count improved the ability to identify high-risk patients when used in conjunction with the FLIPI. These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology.

AB - Follicular lymphoma is characterized by a highly variable clinical course ranging from early transformation and disease-related mortality to prolonged periods of disease stability or even spontaneous remissions. This clinical heterogeneity is likely explained by differences in the tumor microenvironment, including variable infiltration by monocyte-derived cells. Therefore, we examined the absolute monocyte count obtained from a standard complete blood count with differential at the time of diagnosis as a prognostic factor in a cohort of patients with follicular lymphoma (n = 355) treated at a single institution between 1998 and 2007. We found that the absolute monocyte count at diagnosis is associated with overall survival, independent of the Follicular Lymphoma International Prognostic Index (FLIPI). Furthermore, the absolute monocyte count improved the ability to identify high-risk patients when used in conjunction with the FLIPI. These results further support the central role of non-neoplastic myeloid-lineage cells in follicular lymphoma biology.

KW - FLIPI

KW - Follicular lymphoma

KW - Monocyte

KW - Prognosis

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