The ABCs of solute carriers: Physiological, pathological and therapeutic implications of human membrane transport proteins

Matthias A. Hediger, Michael F. Romero, Ji Bin Peng, Andreas Rolfs, Hitomi Takanaga, Elspeth A. Bruford

Research output: Contribution to journalReview article

610 Scopus citations

Abstract

The Human Genome Organisation (HUGO) Nomenclature Committee Database provides a list of transporter families of the solute carrier (SLC) gene series (see http://www.gene.ucl.ac.uk/nomenclature/. Currently, it includes 43 families and 298 transporter genes. This special issue features mini-reviews on each of these SLC families written by the experts in each field. A WEB site has been established (http://www.pharmaconference.org/ slctable.asp) that gives the latest updates for the SLC families and their members as well as relevant links to gene databases and reviews in the literature. A list of all currently known SLC families, a discussion of additional SLC families and family members as well as a brief summary of non-SLC transporter genes is included in this introduction.

Original languageEnglish (US)
Pages (from-to)465-468
Number of pages4
JournalPflugers Archiv European Journal of Physiology
Volume447
Issue number5
DOIs
StatePublished - Feb 1 2004

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Keywords

  • ABC transporter
  • Carrier
  • Channel
  • Cotransporter
  • Coupled transport
  • Exchanger
  • Ion transport
  • Nomenclature
  • Pump
  • SLC
  • Solute transport
  • Transport protein
  • Transporter
  • Transporter gene
  • Uniporter

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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