The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: An independent risk factor for systemic lupus erythematosus in African Americans?

Wael Jarjour, Ann M. Reed, Josée Gauthier, Stephen Hunt, John B. Winfield

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

SLE is dramatically more prevalent in persons of African descent than in other populations. Several genes in the class III region of the MHC have been considered as potential susceptibility loci for this disorder, but the primary association(s) remains unknown. The stress protein gene, hsp70-2, is of special interest in this regard because it encodes a protein functionally relevant to antigen processing and presentation and has itself been identified as a putative susceptibility locus in organ-specific autoimmune diseases in Caucasians. To clarify the relationship of the hsp70-2 gene to SLE in African Americans, genomic DNA from 46 patients and 42 appropriately marched control subjects was analyzed for an RFLP of the hsp70-2 gene using the probe pH2.3 and the restriction endonuclease PstI, which identifies alleles of 8.5 and 9.0 kb. The 8.5-kb hsp270-2 allele was associated with SLE in this population (χ2 = 8.247, p = 0.0044). This association was not due to linkage disequilibrium with the C4A deletion or with HLA-DR3, as has been reported in Caucasians with IDDM. These data suggest that the 8.5-kb hsp70-2 allele may be an independent susceptibility marker for SLE in African Americans.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalHuman Immunology
Volume45
Issue number1
DOIs
StatePublished - Jan 1996
Externally publishedYes

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Heat-Shock Proteins
African Americans
Systemic Lupus Erythematosus
Alleles
Antigen Presentation
Genes
HLA-DR3 Antigen
Linkage Disequilibrium
Type 1 Diabetes Mellitus
Restriction Fragment Length Polymorphisms
Population
Autoimmune Diseases
DNA
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The 8.5-kb PstI allele of the stress protein gene, Hsp70-2 : An independent risk factor for systemic lupus erythematosus in African Americans? / Jarjour, Wael; Reed, Ann M.; Gauthier, Josée; Hunt, Stephen; Winfield, John B.

In: Human Immunology, Vol. 45, No. 1, 01.1996, p. 59-63.

Research output: Contribution to journalArticle

Jarjour, Wael ; Reed, Ann M. ; Gauthier, Josée ; Hunt, Stephen ; Winfield, John B. / The 8.5-kb PstI allele of the stress protein gene, Hsp70-2 : An independent risk factor for systemic lupus erythematosus in African Americans?. In: Human Immunology. 1996 ; Vol. 45, No. 1. pp. 59-63.
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