TY - JOUR
T1 - The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia
T2 - Rationale and important changes
AU - Vardiman, James W.
AU - Thiele, Jüergen
AU - Arber, Daniel A.
AU - Brunning, Richard D.
AU - Borowitz, Michael J.
AU - Porwit, Anna
AU - Harris, Nancy Lee
AU - Le Beau, Michelle M.
AU - Hellström-Lindberg, Eva
AU - Tefferi, Ayalew
AU - Bloomfield, Clara D.
PY - 2009
Y1 - 2009
N2 - Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities - some defined principally by genetic features - that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes.
AB - Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that has emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities - some defined principally by genetic features - that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes.
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U2 - 10.1182/blood-2009-03-209262
DO - 10.1182/blood-2009-03-209262
M3 - Review article
C2 - 19357394
AN - SCOPUS:70349256226
SN - 0006-4971
VL - 114
SP - 937
EP - 951
JO - Blood
JF - Blood
IS - 5
ER -