Thalamic tremor: Correlations with three-dimensional magnetic resonance imaging data and pathophysiological mechanisms

James Howard Bower, Demetrius M. Maraganore, Shannon K. McDonnell, Walter A Rocca

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Tremor associated with a single focal thalamic lesion has rarely been reported. Furthermore, the exact localization of the lesions is difficult to determine because of the imprecision of ″conventional″ radiology (computed tomography scan and/or ″standard″ magnetic resonance imaging). The aim of this study was to identify which thalamic structures are involved in tremor associated with a single focal thalamic lesion. We selected two patients who presented with unilateral postural and kinetic tremor of the upper limb related to a localized thalamic infarction. Three-dimensional T1-weighted magnetic resonance imaging sequence (MP-RAGE sequence) was used to determine the precise topography of the lesions by stereotactic analysis using the atlas of Hassler. The lesions were located within the pulvinar, the sensory nuclei, the mediodorsal nucleus, and the ventral lateral posterior nucleus (according to the classification of Hirai and Jones), the latter including the ventral intermediate nucleus (Vim according to the classification of Hassler). However, the Vim was spared. The subthalamic area, which can induce tremor, was not involved. After having compared the topography of the lesions with the clinical findings, we suggest that thalamic tremors may result from the interruption of the cerebellar outflow tract to the Vim within the thalamus.

Original languageEnglish (US)
Pages (from-to)911-918
Number of pages8
JournalMovement Disorders
Volume15
Issue number5
DOIs
StatePublished - 2000

Fingerprint

Tremor
Magnetic Resonance Imaging
Ventral Thalamic Nuclei
Pulvinar
Lateral Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Atlases
Thalamus
Radiology
Upper Extremity
Infarction
Tomography

Keywords

  • Magnetic resonance imaging
  • Thalamus
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Thalamic tremor : Correlations with three-dimensional magnetic resonance imaging data and pathophysiological mechanisms. / Bower, James Howard; Maraganore, Demetrius M.; McDonnell, Shannon K.; Rocca, Walter A.

In: Movement Disorders, Vol. 15, No. 5, 2000, p. 911-918.

Research output: Contribution to journalArticle

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