Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry

Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L. Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K. Krauss, Marc E. Wolf, Bryan Klassen, Anne Fleur van Rootselaar, Ignacio Regidor, Andrew P. Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T. Mandybur, Michael S. Okun, Karsten Witt, Philip A. StarrGünther Deuschl, Alberto J. Espay

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor.

Original languageEnglish (US)
Pages (from-to)1240-1244
Number of pages5
JournalMovement Disorders
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2017

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Deep Brain Stimulation
Tremor
Activities of Daily Living
Registries

Keywords

  • DBS
  • orthostatic tremor
  • shaky legs
  • treatment
  • Vim

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Merola, A., Fasano, A., Hassan, A., Ostrem, J. L., Contarino, M. F., Lyons, M., ... Espay, A. J. (2017). Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry. Movement Disorders, 32(8), 1240-1244. https://doi.org/10.1002/mds.27082

Thalamic deep brain stimulation for orthostatic tremor : A multicenter international registry. / Merola, Aristide; Fasano, Alfonso; Hassan, Anhar; Ostrem, Jill L.; Contarino, Maria Fiorella; Lyons, Mark; Krauss, Joachim K.; Wolf, Marc E.; Klassen, Bryan; van Rootselaar, Anne Fleur; Regidor, Ignacio; Duker, Andrew P.; Ondo, William; Guridi, Jorge; Volkmann, Jens; Wagle Shukla, Aparna; Mandybur, George T.; Okun, Michael S.; Witt, Karsten; Starr, Philip A.; Deuschl, Günther; Espay, Alberto J.

In: Movement Disorders, Vol. 32, No. 8, 01.08.2017, p. 1240-1244.

Research output: Contribution to journalArticle

Merola, A, Fasano, A, Hassan, A, Ostrem, JL, Contarino, MF, Lyons, M, Krauss, JK, Wolf, ME, Klassen, B, van Rootselaar, AF, Regidor, I, Duker, AP, Ondo, W, Guridi, J, Volkmann, J, Wagle Shukla, A, Mandybur, GT, Okun, MS, Witt, K, Starr, PA, Deuschl, G & Espay, AJ 2017, 'Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry', Movement Disorders, vol. 32, no. 8, pp. 1240-1244. https://doi.org/10.1002/mds.27082
Merola, Aristide ; Fasano, Alfonso ; Hassan, Anhar ; Ostrem, Jill L. ; Contarino, Maria Fiorella ; Lyons, Mark ; Krauss, Joachim K. ; Wolf, Marc E. ; Klassen, Bryan ; van Rootselaar, Anne Fleur ; Regidor, Ignacio ; Duker, Andrew P. ; Ondo, William ; Guridi, Jorge ; Volkmann, Jens ; Wagle Shukla, Aparna ; Mandybur, George T. ; Okun, Michael S. ; Witt, Karsten ; Starr, Philip A. ; Deuschl, Günther ; Espay, Alberto J. / Thalamic deep brain stimulation for orthostatic tremor : A multicenter international registry. In: Movement Disorders. 2017 ; Vol. 32, No. 8. pp. 1240-1244.
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