Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry

Aristide Merola; Alfonso Fasano; Anhar Hassan; Jill L. Ostrem; Maria Fiorella Contarino; Mark Lyons; Joachim K. Krauss; Marc E. Wolf; Bryan T. Klassen; Anne Fleur van Rootselaar; Ignacio Regidor; Andrew P. Duker; William Ondo; Jorge Guridi; Jens Volkmann; Aparna Wagle Shukla; George T. Mandybur; Michael S. Okun; Karsten Witt; Philip A. Starr; Günther Deuschl; Alberto J. Espay

doi:10.1002/mds.27082

Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry

Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L. Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K. Krauss, Marc E. Wolf, Bryan T. Klassen, Anne Fleur van Rootselaar, Ignacio Regidor, Andrew P. Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T. Mandybur, Michael S. Okun, Karsten Witt, Philip A. StarrGünther Deuschl, Alberto J. Espay

Neurology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor.

Original language	English (US)
Pages (from-to)	1240-1244
Number of pages	5
Journal	Movement Disorders
Volume	32
Issue number	8
DOIs	https://doi.org/10.1002/mds.27082
State	Published - Aug 2017

Keywords

DBS
Vim
orthostatic tremor
shaky legs
treatment

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.27082

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Merola, A., Fasano, A., Hassan, A., Ostrem, J. L., Contarino, M. F., Lyons, M., Krauss, J. K., Wolf, M. E., Klassen, B. T., van Rootselaar, A. F., Regidor, I., Duker, A. P., Ondo, W., Guridi, J., Volkmann, J., Wagle Shukla, A., Mandybur, G. T., Okun, M. S., Witt, K., ... Espay, A. J. (2017). Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry. Movement Disorders, 32(8), 1240-1244. https://doi.org/10.1002/mds.27082

Merola, A, Fasano, A, Hassan, A, Ostrem, JL, Contarino, MF, Lyons, M, Krauss, JK, Wolf, ME, Klassen, BT, van Rootselaar, AF, Regidor, I, Duker, AP, Ondo, W, Guridi, J, Volkmann, J, Wagle Shukla, A, Mandybur, GT, Okun, MS, Witt, K, Starr, PA, Deuschl, G & Espay, AJ 2017, 'Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry', Movement Disorders, vol. 32, no. 8, pp. 1240-1244. https://doi.org/10.1002/mds.27082

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title = "Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry",

abstract = "Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor.",

keywords = "DBS, Vim, orthostatic tremor, shaky legs, treatment",

author = "Aristide Merola and Alfonso Fasano and Anhar Hassan and Ostrem, {Jill L.} and Contarino, {Maria Fiorella} and Mark Lyons and Krauss, {Joachim K.} and Wolf, {Marc E.} and Klassen, {Bryan T.} and {van Rootselaar}, {Anne Fleur} and Ignacio Regidor and Duker, {Andrew P.} and William Ondo and Jorge Guridi and Jens Volkmann and {Wagle Shukla}, Aparna and Mandybur, {George T.} and Okun, {Michael S.} and Karsten Witt and Starr, {Philip A.} and G{\"u}nther Deuschl and Espay, {Alberto J.}",

note = "Publisher Copyright: {\textcopyright} 2017 International Parkinson and Movement Disorder Society",

year = "2017",

month = aug,

doi = "10.1002/mds.27082",

language = "English (US)",

volume = "32",

pages = "1240--1244",

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T1 - Thalamic deep brain stimulation for orthostatic tremor

T2 - A multicenter international registry

AU - Merola, Aristide

AU - Fasano, Alfonso

AU - Hassan, Anhar

AU - Ostrem, Jill L.

AU - Contarino, Maria Fiorella

AU - Lyons, Mark

AU - Krauss, Joachim K.

AU - Wolf, Marc E.

AU - Klassen, Bryan T.

AU - van Rootselaar, Anne Fleur

AU - Regidor, Ignacio

AU - Duker, Andrew P.

AU - Ondo, William

AU - Guridi, Jorge

AU - Volkmann, Jens

AU - Wagle Shukla, Aparna

AU - Mandybur, George T.

AU - Okun, Michael S.

AU - Witt, Karsten

AU - Starr, Philip A.

AU - Deuschl, Günther

AU - Espay, Alberto J.

PY - 2017/8

Y1 - 2017/8

N2 - Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor.

AB - Background: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. Methods: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications. Results: There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure. Conclusions: Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor.

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Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry

Abstract

Keywords

ASJC Scopus subject areas

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