Le et al. show that the TGF-β1-TGFβR kinase-SMAD3 pathway protects leukemia cells from PARP inhibitor (PARPi)-mediated synthetic lethality in the bone marrow microenvironment. The targeting of the TGF-β1 axis restored the sensitivity of leukemia cells to PARPi and prolonged survival of leukemia-bearing mice.
- PARP inhibitor resistance
- TGFβR signaling
- bone marrow microenvironment
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)