TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas

Ricardo V. Lloyd, Jorge A. Ferreiro, Long Jin, Tom J. Sebo

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Abstract

Although most papillary thyroid carcinomas behave as low-grade neoplasms and are generally associated with a good prognosis, some subgroups of these neoplasms represent more aggressive variants. In order to determine if differences in the behavior of these papillary carcinomas were related to expression of growth factors or cell-cycle proteins, we analyzed a series of papillary carcinomas including the conventional or usual type (n = 27), tall cell (n = 27), diffuse sclerosing (n = 5), and columnar cell (n = 2) variants for expression of transforming growth factor beta (TGFβ),TGFβ receptors (TGFβ-RI and II, the proliferation marker Ki-67, and for the cell-cycle inhibitory protein p27Kip1 (p27). All groups of thyroid tumors expressed TGFβ and TGFβ-RI and RII by immunohistochemical staining, there was a marked increase in the Ki-67 labeling index after staining with antibody MIB-1 in the columnar cell tumors compared to the other groups, but this difference was not significant because of the small number of tumors in this group. The cell-cycle inhibitory protein p27 was expressed in all groups and was not significantly different between groups. Normal thyroid cells had a higher labeling index for p27 compared to papillary carcinomas. These results indicate that TGFβ and TGFβ receptors I and II are commonly expressed in the usual and in variant forms of papillary thyroid carcinomas, and that there is decreased expression of p27 protein in all of these neoplasms compared to normal thyroid. The biological basis for the more aggressive behavior of these variants of papillary thyroid carcinoma remains uncertain.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalEndocrine Pathology
Volume8
Issue number4
StatePublished - Dec 1997

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Transforming Growth Factor beta Receptors
Transforming Growth Factor beta
Cell Cycle Proteins
Papillary Carcinoma
Neoplasms
Thyroid Gland
Cyclin-Dependent Kinase Inhibitor p27
Staining and Labeling
Papillary Thyroid cancer
Intercellular Signaling Peptides and Proteins

Keywords

  • Ki-67
  • p27
  • Papillary carcinoma
  • Thyroid
  • Transforming growth factor beta

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pathology and Forensic Medicine

Cite this

Lloyd, R. V., Ferreiro, J. A., Jin, L., & Sebo, T. J. (1997). TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas. Endocrine Pathology, 8(4), 293-300.

TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas. / Lloyd, Ricardo V.; Ferreiro, Jorge A.; Jin, Long; Sebo, Tom J.

In: Endocrine Pathology, Vol. 8, No. 4, 12.1997, p. 293-300.

Research output: Contribution to journalArticle

Lloyd, RV, Ferreiro, JA, Jin, L & Sebo, TJ 1997, 'TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas', Endocrine Pathology, vol. 8, no. 4, pp. 293-300.
Lloyd, Ricardo V. ; Ferreiro, Jorge A. ; Jin, Long ; Sebo, Tom J. / TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas. In: Endocrine Pathology. 1997 ; Vol. 8, No. 4. pp. 293-300.
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