TY - JOUR
T1 - TGFβ-mediated signaling and transcriptional regulation in pancreatic development and cancer
AU - Ellenrieder, Volker
AU - Fernandez Zapico, Martin E.
AU - Urrutia, Raul
PY - 2001
Y1 - 2001
N2 - Transforming growth factor-β (TGFβ) plays a critical role in pancreatic development and cell proliferation. Binding of TGFβ to its membrane receptor kinases activates the Smad signaling proteins, allowing them to translocate to the nucleus and participate in the transcriptional control of TGFβ target genes. In addition, there is an increasing number of cellular mechanisms affecting the final response of a cell to TGFβ. This includes crosstalk with other signaling pathways and the induction of TGFβ early response genes, such as the TGFβ-inducible early response gene (TIEG) family of transcription factors. Like the Smads, TIEGs behave as downstream effector proteins in TGFβ-mediated pancreatic growth control. The discovery of the Smads and TIEGs has provided new insights into TGFβ-regulated functions. Their significance in pancreatic development and cancer is discussed in this review.
AB - Transforming growth factor-β (TGFβ) plays a critical role in pancreatic development and cell proliferation. Binding of TGFβ to its membrane receptor kinases activates the Smad signaling proteins, allowing them to translocate to the nucleus and participate in the transcriptional control of TGFβ target genes. In addition, there is an increasing number of cellular mechanisms affecting the final response of a cell to TGFβ. This includes crosstalk with other signaling pathways and the induction of TGFβ early response genes, such as the TGFβ-inducible early response gene (TIEG) family of transcription factors. Like the Smads, TIEGs behave as downstream effector proteins in TGFβ-mediated pancreatic growth control. The discovery of the Smads and TIEGs has provided new insights into TGFβ-regulated functions. Their significance in pancreatic development and cancer is discussed in this review.
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U2 - 10.1097/00001574-200109000-00006
DO - 10.1097/00001574-200109000-00006
M3 - Review article
C2 - 17031197
AN - SCOPUS:0034866971
SN - 0267-1379
VL - 17
SP - 434
EP - 440
JO - Current Opinion in Gastroenterology
JF - Current Opinion in Gastroenterology
IS - 5
ER -