TFAR19 gene changes the biophysical properties of murine erythroleukemia cells

Li Gu, Yuhui Jiang, Ying Wang, Weijuan Yao, Dagong Sun, Weibo Ka, Zhiyu Tang, Xiaofeng Xu, Zongyao Wen, Shu Chien

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

TFAR19 is a novel apoptosis-related gene and can accelerate cell apoptosis in the presence of apoptosis inducements. Here, we studied the effects of TFAR19 on some biophysical properties of mouse erythroleukemia (MEL) cells and their molecular and structural basis. After transfected with TFAR19 and apoptosis inducement, MEL revealed a high cell membrane fluidity, a decrease in resynthesis of phospholipids, an increase in the proteins/nucleic acids ratio, a relatively orderly cytoskeleton network, an impaired deformability a low integrin aM expression, and a decrease in adhesion to endothelial cells. These findings suggest the potential of TFAR19 for antitumor cell migration, and thus for antitumor gene therapy.

Original languageEnglish (US)
Pages (from-to)355-363
Number of pages9
JournalCell Biochemistry and Biophysics
Volume43
Issue number3
DOIs
StatePublished - Nov 2005

Keywords

  • Adhesion
  • Apoptosis
  • Deformability
  • Murine erythroleukemia cell line (MEL)
  • Programmed cell death 5 (PDCD5)
  • TF-1 cells apoptosis-related gene 19 (TFAR19)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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