Abstract
Objective: To develop an efficient space-frequency transform for texture analysis and demonstrate its application on magnetic resonance (MR) images of multiple sclerosis (MS) patients. Materials and methods: We applied our new transform to MR images of three enhancing lesions from two relapsing-remitting MS patients acquired serially over 9 months. Local spectra of the images were generated using our new technique, and spatial frequencies corresponding to MS lesion activity were extracted by applying a band-pass filter and inverting. We examined the changes in T2 intensity and low-frequency energy (LFE) over time within the lesion, surrounding tissue and a region of normal-appearing white matter (NAWM). Results: We calculated complex local spectra of 428 × 428 images in approximately 1 min and achieved a spatial frequency resolution of 0.05 cm-1. We observed an increase in LFE within the lesion and a drop in LFE in the hyperintense border of tissue surrounding the lesion. Conclusion: We have developed an efficient, invertible transform that produces high-resolution local frequency spectra of an MR image in approximately 1 min. Negative LFE values in the boundaries of an active lesion may help discriminate between the core lesion undergoing demyelination and a border of inflammation.
Original language | English (US) |
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Pages (from-to) | 465-475 |
Number of pages | 11 |
Journal | International Journal of Computer Assisted Radiology and Surgery |
Volume | 3 |
Issue number | 5 |
DOIs | |
State | Published - 2008 |
Keywords
- Computer-assisted image interpretation
- Fourier analysis
- Magnetic resonance imaging
- Multiple sclerosis
ASJC Scopus subject areas
- Surgery
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
- Computer Vision and Pattern Recognition
- Health Informatics
- Computer Science Applications
- Computer Graphics and Computer-Aided Design