Texture analysis of MR images of minocycline treated MS patients

Yunyan Zhang, Hongmei Zhu, Ricardo Ferrari, Xingchang Wei, Michael Eliasziw, Luanne M. Metz, J. Ross Mitchell

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Texture analysis was applied to 3T brain MR images of 5 relapsing remitting MS patients before and after minocycline treatment. Texture features were used to quantify pathological changes that may be undetectable by conventional MR techniques. Active, inactive lesions and NAWM were chosen from MR images of MS patients one month before and six months after treatment. Texture features changed in all of the selected ROIs. Texture change in active lesions was greater than that in inactive lesions and NAWM. There was close relationship between texture changes in active lesions and NAWM. This preliminary work suggests that it may be possible to predict therapeutic response of MS patients using MRI texture analysis.

Original languageEnglish (US)
Pages (from-to)786-793
Number of pages8
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume2878
StatePublished - Dec 1 2003

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ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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