Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature

Samir M. Dalia; Pedro Horna; Ling Zhang

Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature

Samir M. Dalia, Pedro Horna, Ling Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.

Original language	English (US)
Pages (from-to)	5363-5368
Number of pages	6
Journal	International Journal of Clinical and Experimental Pathology
Volume	7
Issue number	8
State	Published - Jan 1 2014

Keywords

Acute promyelocytic leukemia
All trans-retinoic acid (ATRA)
Leukemia
PML-RARA
Tetraploid

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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abstract = "Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.",

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AU - Horna, Pedro

AU - Zhang, Ling

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N2 - Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.

AB - Acute promyelocytic leukemia (APL) with tetraploidy chromosome harboring t(15;17)(q23;a21) is extremely rare. To date, there are 14 such cases reports that describe this entity, mostly found in Eastern hemisphere. Herein we described a 51-year-old man with a diagnosis of tetraploid acute promyelocytic leukemia with double (15;17) translocations and compare the prototypically clinicopathologic, genetic and molecular findings with those reported in the literature.

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KW - All trans-retinoic acid (ATRA)

KW - Leukemia

KW - PML-RARA

KW - Tetraploid

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Tetraploidy acute promyelocytic leuemia with double t(15;17)/PML-RARA, a case report with review of literature

Abstract

Keywords

ASJC Scopus subject areas

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