Tetralogy of Fallot repair in patients 40 years or older

Christine H.Attenhofer Jost, Heidi M. Connolly, Harold M. Burkhart, Christopher G. Scott, Joseph A. Dearani, Aisling J. Carroll, A. Jamil Tajik

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

OBJECTIVE: To report the outcomes of patients with tetralogy of Fallot (TOF) undergoing surgical repair at age 40 years or older. PATIENTS AND METHODS: We reviewed records of patients (age, ≥40 years) who underwent TOF repair from January 1, 1970, through December 31, 2007. Symptoms, palliative procedures, surgical reports, and long-term outcomes were analyzed. RESULTS: Fifty-two patients (30 men [58%]) had surgery at a mean ± SD age of 50±8 years; 27 (52%) had prior palliative surgery at a mean ± SD age of 17±11 years. Procedures for TOF repair included pulmonary valve replacement (n=10), transannular patch (n=10), and native pulmonary valve preservation (n=32). The 30-day mortality rate was 6% (stroke, n=2; ventricular fibrillation, n=1). A mean ± SD follow-up of 14.9±9.3 years was feasible in 48 of 49 survivors; improvement in functional class was observed in 42 patients. Reoperation was performed in 7 patients (4 for pulmonary regurgitation). Twenty-nine patients died (mean ± SD age, 65±12 years); causes of death were cardiac (n=7), noncardiac (n=4), and unknown (n=18). Mean ± SD age at death was younger in patients with previous palliation (59±11 years vs 70±12 years; P=.03). The 10-year survival rate was lower than expected compared with an age- and sex-matched population (73% vs 91%; P<.001). CONCLUSION: Complete repair of TOF in patients 40 years or older is feasible but carries increased operative risk. Surgical survivors have improvement in functional class; however, survival remains lower than expected. Reduced survival and need for reoperation emphasize the importance of pulmonary valve replacement at the time of initial repair and long-term follow-up.

Original languageEnglish (US)
Pages (from-to)1090-1094
Number of pages5
JournalMayo Clinic proceedings
Volume85
Issue number12
DOIs
StatePublished - Dec 2010

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Tetralogy of Fallot repair in patients 40 years or older'. Together they form a unique fingerprint.

  • Cite this

    Jost, C. H. A., Connolly, H. M., Burkhart, H. M., Scott, C. G., Dearani, J. A., Carroll, A. J., & Tajik, A. J. (2010). Tetralogy of Fallot repair in patients 40 years or older. Mayo Clinic proceedings, 85(12), 1090-1094. https://doi.org/10.4065/mcp.2010.0286