Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone

Hiroyuki Kinoshita, Masato Tsutsui, Sheldon Milstien, Zvonimir S Katusic

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Tetrahydrobiopterin is an essential cofactor required for activity of nitric oxide synthases. Existing evidence suggests that, during activation of constitutive and inducible isoforms of nitric oxide synthase, tetrahydrobiopterin is needed for allosteric and redox activation of enzymetic activity. However, precise mechanisms underlying the role of tetrahydrobiopterin in regulation of nitric oxide formation is not fully understood. In cerebral and peripheral arteries, increased availability of tetrahydrobiopterin can augment production of nitric oxide. In contrast, in arteries depleted of tetrahydrobiopterin, production of nitric oxide is impaired. Proinflammatory cytokines enhance mRNA expression of the rate- limiting enzyme of tetrahydrobiopterin biosynthesis. GTP cyclohydrolase I and stimulate production of tetrahydrobiopterin. The ability of vascular tissues to synthesize tetrahydrobiopterin plays an important role in regulation of nitric oxide synthase under physiological conditions as well as during inflammation and sepsis. More recent studies concerning expression and function of recombinant nitric oxide synthases suggest that availability of tetrahydrobiopterin is important for production of nitric oxide in genetically engineered blood vessels. In this review, mechanisms regulating availability of intracellular tetrabydrobiopterin and its role in control of vascular tone under physiological and pathological conditions will be discussed.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalProgress in Neurobiology
Volume52
Issue number4
DOIs
StatePublished - Jul 1997

Fingerprint

Nitric Oxide
Nitric Oxide Synthase
Blood Vessels
GTP Cyclohydrolase
sapropterin
Cerebral Arteries
Nitric Oxide Synthase Type II
Oxidation-Reduction
Sepsis
Protein Isoforms
Arteries
Cytokines
Inflammation
Messenger RNA
Enzymes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone. / Kinoshita, Hiroyuki; Tsutsui, Masato; Milstien, Sheldon; Katusic, Zvonimir S.

In: Progress in Neurobiology, Vol. 52, No. 4, 07.1997, p. 295-302.

Research output: Contribution to journalArticle

Kinoshita, Hiroyuki ; Tsutsui, Masato ; Milstien, Sheldon ; Katusic, Zvonimir S. / Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone. In: Progress in Neurobiology. 1997 ; Vol. 52, No. 4. pp. 295-302.
@article{cd292e95405d49d7a7b014c9d68b50fd,
title = "Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone",
abstract = "Tetrahydrobiopterin is an essential cofactor required for activity of nitric oxide synthases. Existing evidence suggests that, during activation of constitutive and inducible isoforms of nitric oxide synthase, tetrahydrobiopterin is needed for allosteric and redox activation of enzymetic activity. However, precise mechanisms underlying the role of tetrahydrobiopterin in regulation of nitric oxide formation is not fully understood. In cerebral and peripheral arteries, increased availability of tetrahydrobiopterin can augment production of nitric oxide. In contrast, in arteries depleted of tetrahydrobiopterin, production of nitric oxide is impaired. Proinflammatory cytokines enhance mRNA expression of the rate- limiting enzyme of tetrahydrobiopterin biosynthesis. GTP cyclohydrolase I and stimulate production of tetrahydrobiopterin. The ability of vascular tissues to synthesize tetrahydrobiopterin plays an important role in regulation of nitric oxide synthase under physiological conditions as well as during inflammation and sepsis. More recent studies concerning expression and function of recombinant nitric oxide synthases suggest that availability of tetrahydrobiopterin is important for production of nitric oxide in genetically engineered blood vessels. In this review, mechanisms regulating availability of intracellular tetrabydrobiopterin and its role in control of vascular tone under physiological and pathological conditions will be discussed.",
author = "Hiroyuki Kinoshita and Masato Tsutsui and Sheldon Milstien and Katusic, {Zvonimir S}",
year = "1997",
month = "7",
doi = "10.1016/S0301-0082(97)00017-8",
language = "English (US)",
volume = "52",
pages = "295--302",
journal = "Progress in Neurobiology",
issn = "0301-0082",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone

AU - Kinoshita, Hiroyuki

AU - Tsutsui, Masato

AU - Milstien, Sheldon

AU - Katusic, Zvonimir S

PY - 1997/7

Y1 - 1997/7

N2 - Tetrahydrobiopterin is an essential cofactor required for activity of nitric oxide synthases. Existing evidence suggests that, during activation of constitutive and inducible isoforms of nitric oxide synthase, tetrahydrobiopterin is needed for allosteric and redox activation of enzymetic activity. However, precise mechanisms underlying the role of tetrahydrobiopterin in regulation of nitric oxide formation is not fully understood. In cerebral and peripheral arteries, increased availability of tetrahydrobiopterin can augment production of nitric oxide. In contrast, in arteries depleted of tetrahydrobiopterin, production of nitric oxide is impaired. Proinflammatory cytokines enhance mRNA expression of the rate- limiting enzyme of tetrahydrobiopterin biosynthesis. GTP cyclohydrolase I and stimulate production of tetrahydrobiopterin. The ability of vascular tissues to synthesize tetrahydrobiopterin plays an important role in regulation of nitric oxide synthase under physiological conditions as well as during inflammation and sepsis. More recent studies concerning expression and function of recombinant nitric oxide synthases suggest that availability of tetrahydrobiopterin is important for production of nitric oxide in genetically engineered blood vessels. In this review, mechanisms regulating availability of intracellular tetrabydrobiopterin and its role in control of vascular tone under physiological and pathological conditions will be discussed.

AB - Tetrahydrobiopterin is an essential cofactor required for activity of nitric oxide synthases. Existing evidence suggests that, during activation of constitutive and inducible isoforms of nitric oxide synthase, tetrahydrobiopterin is needed for allosteric and redox activation of enzymetic activity. However, precise mechanisms underlying the role of tetrahydrobiopterin in regulation of nitric oxide formation is not fully understood. In cerebral and peripheral arteries, increased availability of tetrahydrobiopterin can augment production of nitric oxide. In contrast, in arteries depleted of tetrahydrobiopterin, production of nitric oxide is impaired. Proinflammatory cytokines enhance mRNA expression of the rate- limiting enzyme of tetrahydrobiopterin biosynthesis. GTP cyclohydrolase I and stimulate production of tetrahydrobiopterin. The ability of vascular tissues to synthesize tetrahydrobiopterin plays an important role in regulation of nitric oxide synthase under physiological conditions as well as during inflammation and sepsis. More recent studies concerning expression and function of recombinant nitric oxide synthases suggest that availability of tetrahydrobiopterin is important for production of nitric oxide in genetically engineered blood vessels. In this review, mechanisms regulating availability of intracellular tetrabydrobiopterin and its role in control of vascular tone under physiological and pathological conditions will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=0030798048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030798048&partnerID=8YFLogxK

U2 - 10.1016/S0301-0082(97)00017-8

DO - 10.1016/S0301-0082(97)00017-8

M3 - Article

VL - 52

SP - 295

EP - 302

JO - Progress in Neurobiology

JF - Progress in Neurobiology

SN - 0301-0082

IS - 4

ER -