Testicular plasmacytoma following chemical orchiectomy: Potential role of hypogonadism in myeloma proliferation

Walter H. Kahr, Aziz Al-Homadhi, Jacinta Meharchand, Dennis J. Bailey, A. Keith Stewart

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We present a case of a 55 year old man with multiple myeloma who underwent autologous stem cell transplantation and subsequently developed testicular myeloma. Testicular enlargement was observed only after treatment of an incidental prostatic adenocarcinoma with chemical orchidectomy at a time when myeloma was controlled systemically. A subsequent bilateral surgical orchiectomy revealed plasmacytoma in both testis. Enhanced production of B-lymphocytes after castration has been reported and implicates testosterone as a possible negative regulator of B-cell production. We propose that the androgen deficient state may have contributed to the development of plasmacytoma of the testes in our patient. The regulatory role of sex steroids in B-cell development is discussed.

Original languageEnglish (US)
Pages (from-to)437-442
Number of pages6
JournalLeukemia and Lymphoma
Volume28
Issue number3-4
StatePublished - Mar 21 1998

Keywords

  • Androgen deficient state
  • B-cell development
  • Multiple myeloma
  • Orchiectomy
  • Plasmacytoma
  • Sex hormones
  • Sex steroids

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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