Abstract
We present a case of a 55 year old man with multiple myeloma who underwent autologous stem cell transplantation and subsequently developed testicular myeloma. Testicular enlargement was observed only after treatment of an incidental prostatic adenocarcinoma with chemical orchidectomy at a time when myeloma was controlled systemically. A subsequent bilateral surgical orchiectomy revealed plasmacytoma in both testis. Enhanced production of B-lymphocytes after castration has been reported and implicates testosterone as a possible negative regulator of B-cell production. We propose that the androgen deficient state may have contributed to the development of plasmacytoma of the testes in our patient. The regulatory role of sex steroids in B-cell development is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-442 |
| Number of pages | 6 |
| Journal | Leukemia and Lymphoma |
| Volume | 28 |
| Issue number | 3-4 |
| State | Published - 1998 |
Keywords
- Androgen deficient state
- B-cell development
- Multiple myeloma
- Orchiectomy
- Plasmacytoma
- Sex hormones
- Sex steroids
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research