Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease

The PREVENT-AD Research Group

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the "Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease" (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ∼3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.

Original languageEnglish (US)
Article number150043
JournalScientific data
Volume2
DOIs
StatePublished - Oct 13 2015

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Alzheimer's Disease
Functional Magnetic Resonance Imaging
genealogy
dementia
Person
human being
Neuroimaging
Randomized Clinical Trial
Dementia
Reproducibility
Treatment Effects
Spatial Distribution
Spatial distribution
Registration
Seed
Connectivity
Metric
Resources
Motion
Evaluation

ASJC Scopus subject areas

  • Education
  • Library and Information Sciences
  • Computer Science Applications
  • Information Systems
  • Statistics, Probability and Uncertainty
  • Statistics and Probability

Cite this

Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease. / The PREVENT-AD Research Group.

In: Scientific data, Vol. 2, 150043, 13.10.2015.

Research output: Contribution to journalArticle

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