TY - JOUR
T1 - Test-Retest Reliability of Health-Related Quality-of-Life Questionnaires in Adults with Strabismus
AU - Leske, David A.
AU - Hatt, Sarah R.
AU - Holmes, Jonathan M.
N1 - Funding Information:
Supported by Grants EY015799 and EY018810 (J.M.H.) from the National Institutes of Health, Bethesda, Maryland ; Research to Prevent Blindness, Inc, New York, New York (J.M.H. as Olga Keith Weiss Scholar and an unrestricted grant to the Department of Ophthalmology, Mayo Clinic); and the Mayo Foundation, Rochester, Minnesota. Involved in design of the study (D.A.L., S.R.H., J.M.H.); Conduct of the study (D.A.L., S.R.H., J.M.H.); Collection of data (S.R.H., J.M.H.); Management, of data (D.A.L., S.R.H., J.M.H.); Analysis of data (D.A.L., J.M.H.); Interpretation of data (D.A.L., S.R.H., J.M.H.); and Preparation, review, and approval of manuscript (D.A.L., S.R.H., J.M.H.). Institutional review board approval was obtained at the authors' institution and each patient gave informed consent before participating. All procedures and data collection were conducted in a manner compliant with the Health Insurance Portability and Accountability Act.
PY - 2010/4
Y1 - 2010/4
N2 - Purpose: To report the test-retest variability of two health-related quality-of-life instruments: the new Adult Strabismus 20 (AS-20) and the National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25), in adults with strabismus. Design: Prospective case series. Methods: Fifty-five adult patients in a clinical practice with stable strabismus completed the AS-20 and the NEI VFQ-25 at 2 visits, without intervening treatment. Questionnaires were completed the second time either at a subsequent office visit, immediately before surgery, or by mail. Intraclass correlation coefficients were calculated. Ninety-five percent limits of agreement and 95% confidence intervals around the 95% limits of agreement also were calculated. Results: There was excellent agreement of overall questionnaire scores for the AS-20 (intraclass correlation coefficient, 0.92) and NEI VFQ-25 (intraclass correlation coefficient, 0.94). The 95% limits of agreement for overall scores were 14.3 points (95% confidence interval, 10.9 to 17.7) for the AS-20 and 11.1 points (95% confidence interval, 8.5 to 13.8) for the NEI VFQ-25. The lower test-retest variability of the VFQ-25 seemed to be partly the result of ceiling effects with many scores at the normal end of the range. Conclusions: The new AS-20 and the NEI VFQ-25 show excellent test-retest reliability in adults with strabismus. Change exceeding 95% limits of agreement (14 points on the AS-20 and 11 points on the VFQ-25) is indicative of real change in an individual patient. The AS-20 may be more useful than the VFQ-25 because it is less prone to ceiling effects in adults with strabismus.
AB - Purpose: To report the test-retest variability of two health-related quality-of-life instruments: the new Adult Strabismus 20 (AS-20) and the National Eye Institute 25-item Visual Function Questionnaire (NEI VFQ-25), in adults with strabismus. Design: Prospective case series. Methods: Fifty-five adult patients in a clinical practice with stable strabismus completed the AS-20 and the NEI VFQ-25 at 2 visits, without intervening treatment. Questionnaires were completed the second time either at a subsequent office visit, immediately before surgery, or by mail. Intraclass correlation coefficients were calculated. Ninety-five percent limits of agreement and 95% confidence intervals around the 95% limits of agreement also were calculated. Results: There was excellent agreement of overall questionnaire scores for the AS-20 (intraclass correlation coefficient, 0.92) and NEI VFQ-25 (intraclass correlation coefficient, 0.94). The 95% limits of agreement for overall scores were 14.3 points (95% confidence interval, 10.9 to 17.7) for the AS-20 and 11.1 points (95% confidence interval, 8.5 to 13.8) for the NEI VFQ-25. The lower test-retest variability of the VFQ-25 seemed to be partly the result of ceiling effects with many scores at the normal end of the range. Conclusions: The new AS-20 and the NEI VFQ-25 show excellent test-retest reliability in adults with strabismus. Change exceeding 95% limits of agreement (14 points on the AS-20 and 11 points on the VFQ-25) is indicative of real change in an individual patient. The AS-20 may be more useful than the VFQ-25 because it is less prone to ceiling effects in adults with strabismus.
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U2 - 10.1016/j.ajo.2009.11.004
DO - 10.1016/j.ajo.2009.11.004
M3 - Article
C2 - 20138603
AN - SCOPUS:77949654255
SN - 0002-9394
VL - 149
SP - 672
EP - 676
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 4
ER -