Ten-year clinical outcomes of an intermediate coronary lesion; prognosis and predictors of major adverse cardiovascular events

Jang Ho Bae, Michel T. Corban, Young Hoon Seo, Taewon Kim, Gahyeong Lee, Taek Geun Kwon, Ki Hong Kim, In Geol Song, Moo Sik Lee, Charanjit Rihal, Amir Lerman

Research output: Contribution to journalArticle

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Abstract

Aims: The natural history of intermediate coronary lesions (30 to 70% angiographic stenosis) and the prognostic predictors in predicting very long-term clinical outcomes is unknown. Methods: Patients (n = 82, mean 60 years old) with intermediate non-culprit coronary lesions (NCL, n = 86), evaluated by virtual histology-intravascular ultrasound (VH-IVUS), were followed for 10 years. Major adverse cardiovascular events (MACE; all-cause death, myocardial infarction, stroke, and revascularization) were collected over follow-up period and stratified by culprit lesion (CL)-related, NCL-related and indeterminate/unrelated to CL or NCL lesions. NCL-related MACE was further stratified into intermediate and minimal NCL-related events. Results: Twenty two (25.6%) out of 86 intermediate NCL were associated with MACE in 20/82 (24.4%) study patients. Ten-year cumulative intermediate NCL-related MACE rate was twice (25.6% vs. 12.8%) compared to treated culprit lesion (CL)-related MACE. Ten-year cumulative revascularization rate of the intermediate NCL lesions was similar (17.4% vs. 15.1%) to those of CL, but higher than that of minimal (stenosed <30% at baseline) NCL (8.1%). Important intermediate NCL VH-IVUS predictor for MACE was area stenosis ≥50%, and for revascularization were percent diameter stenosis, plaque burden ≥70%, and fibrofatty area. Conclusions: Ten-year MACE rate of intermediate NCL was double that of CL and ten-year revascularization rate of intermediate NCL was similar or slightly higher than that of CL. VH-IVUS may play an important role in determining the very long-term clinical outcomes in patients with intermediate NCL. This study suggests that Intermediate NCL can be safely followed up in terms of revascularization risk.

Original languageEnglish (US)
JournalInternational Journal of Cardiology
DOIs
StatePublished - Jan 1 2019

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Histology
Pathologic Constriction
Myocardial Revascularization
Natural History
Cause of Death
Stroke
Myocardial Infarction
6-astatomethyl-19-norcholest-5(10)-en-3-ol

Keywords

  • Coronary artery stenosis
  • Intermediate coronary lesion
  • Intravascular ultrasonography
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ten-year clinical outcomes of an intermediate coronary lesion; prognosis and predictors of major adverse cardiovascular events. / Bae, Jang Ho; Corban, Michel T.; Seo, Young Hoon; Kim, Taewon; Lee, Gahyeong; Kwon, Taek Geun; Kim, Ki Hong; Song, In Geol; Lee, Moo Sik; Rihal, Charanjit; Lerman, Amir.

In: International Journal of Cardiology, 01.01.2019.

Research output: Contribution to journalArticle

Bae, Jang Ho ; Corban, Michel T. ; Seo, Young Hoon ; Kim, Taewon ; Lee, Gahyeong ; Kwon, Taek Geun ; Kim, Ki Hong ; Song, In Geol ; Lee, Moo Sik ; Rihal, Charanjit ; Lerman, Amir. / Ten-year clinical outcomes of an intermediate coronary lesion; prognosis and predictors of major adverse cardiovascular events. In: International Journal of Cardiology. 2019.
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abstract = "Aims: The natural history of intermediate coronary lesions (30 to 70{\%} angiographic stenosis) and the prognostic predictors in predicting very long-term clinical outcomes is unknown. Methods: Patients (n = 82, mean 60 years old) with intermediate non-culprit coronary lesions (NCL, n = 86), evaluated by virtual histology-intravascular ultrasound (VH-IVUS), were followed for 10 years. Major adverse cardiovascular events (MACE; all-cause death, myocardial infarction, stroke, and revascularization) were collected over follow-up period and stratified by culprit lesion (CL)-related, NCL-related and indeterminate/unrelated to CL or NCL lesions. NCL-related MACE was further stratified into intermediate and minimal NCL-related events. Results: Twenty two (25.6{\%}) out of 86 intermediate NCL were associated with MACE in 20/82 (24.4{\%}) study patients. Ten-year cumulative intermediate NCL-related MACE rate was twice (25.6{\%} vs. 12.8{\%}) compared to treated culprit lesion (CL)-related MACE. Ten-year cumulative revascularization rate of the intermediate NCL lesions was similar (17.4{\%} vs. 15.1{\%}) to those of CL, but higher than that of minimal (stenosed <30{\%} at baseline) NCL (8.1{\%}). Important intermediate NCL VH-IVUS predictor for MACE was area stenosis ≥50{\%}, and for revascularization were percent diameter stenosis, plaque burden ≥70{\%}, and fibrofatty area. Conclusions: Ten-year MACE rate of intermediate NCL was double that of CL and ten-year revascularization rate of intermediate NCL was similar or slightly higher than that of CL. VH-IVUS may play an important role in determining the very long-term clinical outcomes in patients with intermediate NCL. This study suggests that Intermediate NCL can be safely followed up in terms of revascularization risk.",
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author = "Bae, {Jang Ho} and Corban, {Michel T.} and Seo, {Young Hoon} and Taewon Kim and Gahyeong Lee and Kwon, {Taek Geun} and Kim, {Ki Hong} and Song, {In Geol} and Lee, {Moo Sik} and Charanjit Rihal and Amir Lerman",
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AU - Bae, Jang Ho

AU - Corban, Michel T.

AU - Seo, Young Hoon

AU - Kim, Taewon

AU - Lee, Gahyeong

AU - Kwon, Taek Geun

AU - Kim, Ki Hong

AU - Song, In Geol

AU - Lee, Moo Sik

AU - Rihal, Charanjit

AU - Lerman, Amir

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N2 - Aims: The natural history of intermediate coronary lesions (30 to 70% angiographic stenosis) and the prognostic predictors in predicting very long-term clinical outcomes is unknown. Methods: Patients (n = 82, mean 60 years old) with intermediate non-culprit coronary lesions (NCL, n = 86), evaluated by virtual histology-intravascular ultrasound (VH-IVUS), were followed for 10 years. Major adverse cardiovascular events (MACE; all-cause death, myocardial infarction, stroke, and revascularization) were collected over follow-up period and stratified by culprit lesion (CL)-related, NCL-related and indeterminate/unrelated to CL or NCL lesions. NCL-related MACE was further stratified into intermediate and minimal NCL-related events. Results: Twenty two (25.6%) out of 86 intermediate NCL were associated with MACE in 20/82 (24.4%) study patients. Ten-year cumulative intermediate NCL-related MACE rate was twice (25.6% vs. 12.8%) compared to treated culprit lesion (CL)-related MACE. Ten-year cumulative revascularization rate of the intermediate NCL lesions was similar (17.4% vs. 15.1%) to those of CL, but higher than that of minimal (stenosed <30% at baseline) NCL (8.1%). Important intermediate NCL VH-IVUS predictor for MACE was area stenosis ≥50%, and for revascularization were percent diameter stenosis, plaque burden ≥70%, and fibrofatty area. Conclusions: Ten-year MACE rate of intermediate NCL was double that of CL and ten-year revascularization rate of intermediate NCL was similar or slightly higher than that of CL. VH-IVUS may play an important role in determining the very long-term clinical outcomes in patients with intermediate NCL. This study suggests that Intermediate NCL can be safely followed up in terms of revascularization risk.

AB - Aims: The natural history of intermediate coronary lesions (30 to 70% angiographic stenosis) and the prognostic predictors in predicting very long-term clinical outcomes is unknown. Methods: Patients (n = 82, mean 60 years old) with intermediate non-culprit coronary lesions (NCL, n = 86), evaluated by virtual histology-intravascular ultrasound (VH-IVUS), were followed for 10 years. Major adverse cardiovascular events (MACE; all-cause death, myocardial infarction, stroke, and revascularization) were collected over follow-up period and stratified by culprit lesion (CL)-related, NCL-related and indeterminate/unrelated to CL or NCL lesions. NCL-related MACE was further stratified into intermediate and minimal NCL-related events. Results: Twenty two (25.6%) out of 86 intermediate NCL were associated with MACE in 20/82 (24.4%) study patients. Ten-year cumulative intermediate NCL-related MACE rate was twice (25.6% vs. 12.8%) compared to treated culprit lesion (CL)-related MACE. Ten-year cumulative revascularization rate of the intermediate NCL lesions was similar (17.4% vs. 15.1%) to those of CL, but higher than that of minimal (stenosed <30% at baseline) NCL (8.1%). Important intermediate NCL VH-IVUS predictor for MACE was area stenosis ≥50%, and for revascularization were percent diameter stenosis, plaque burden ≥70%, and fibrofatty area. Conclusions: Ten-year MACE rate of intermediate NCL was double that of CL and ten-year revascularization rate of intermediate NCL was similar or slightly higher than that of CL. VH-IVUS may play an important role in determining the very long-term clinical outcomes in patients with intermediate NCL. This study suggests that Intermediate NCL can be safely followed up in terms of revascularization risk.

KW - Coronary artery stenosis

KW - Intermediate coronary lesion

KW - Intravascular ultrasonography

KW - Prognosis

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