Temporospatial Expression of Fgfr1 and 2 During Lung Development, Homeostasis, and Regeneration

Tingting Yuan, Kylie Klinkhammer, Handeng Lyu, Shan Gao, Jie Yuan, Seantel Hopkins, Jin San Zhang, Stijn P. De Langhe

Research output: Contribution to journalArticlepeer-review

Abstract

Fgfr1 (Fibroblast growth factor receptor 1) and Fgfr2 are dynamically expressed during lung development, homeostasis, and regeneration. Our current analysis indicates that Fgfr2 is expressed in distal epithelial progenitors AT2, AT1, club, and basal cells but not in ciliated or neuroendocrine cells during lung development and homeostasis. However, after injury, Fgfr2 becomes upregulated in neuroendocrine cells and distal club cells. Epithelial Fgfr1 expression is minimal throughout lung development, homeostasis, and regeneration. We further find both Fgfr1 and Fgfr2 strongly expressed in cartilage progenitors and airway smooth muscle cells during lung development, whereas Fgfr1 but not Fgfr2 was expressed in lipofibroblasts and vascular smooth muscle cells. In the adult lung, Fgfr1 and Fgfr2 were mostly downregulated in smooth muscle cells but became upregulated after injury. Fgfr1 remained expressed in mesenchymal alveolar niche cells or lipofibroblasts with lower levels of expression in their descendant (alveolar) myofibroblasts during alveologenesis.

Original languageEnglish (US)
Article number120
JournalFrontiers in Pharmacology
Volume11
DOIs
StatePublished - Mar 2 2020

Keywords

  • development
  • Fgf
  • homeostasis
  • lung
  • regeneration

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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