Temporoparietal atrophy: A marker of AD pathology independent of clinical diagnosis

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Alzheimer's disease (AD) can present with non-amnestic clinical syndromes. We investigated whether there is an imaging signature of AD pathology in these atypical subjects. We identified 14 subjects that had pathological AD, a non-amnestic presentation (i.e. atypical AD), and MRI. These subjects were matched to 14 with clinical and pathological AD (i.e. typical AD), 14 with the same non-amnestic presentations with frontotemporal lobar degeneration (FTLD) pathology, and 20 controls. Voxel-based morphometry and region-of-interest (ROI) analysis were used to assess patterns of grey matter loss. Loss was observed in the temporoparietal cortex in both typical and atypical AD, and showed significantly greater loss than FTLD. However, the medial temporal lobes were more severely affected in typical AD and FTLD compared to atypical AD. A ratio of hippocampal and temporoparietal volumes provided excellent discrimination of atypical AD from FTLD subjects. Temporoparietal atrophy may therefore provide a useful marker of the presence of AD pathology even in subjects with atypical clinical presentations, especially in the context of relative sparing of the hippocampus.

Original languageEnglish (US)
Pages (from-to)1531-1541
Number of pages11
JournalNeurobiology of aging
Volume32
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Alzheimer's disease
  • Frontotemporal lobar degeneration
  • Hippocampus
  • Non-amnestic presentation
  • Pathology
  • Temporoparietal cortex
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Temporoparietal atrophy: A marker of AD pathology independent of clinical diagnosis'. Together they form a unique fingerprint.

  • Cite this