Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering

Richard G. Payne; Alan W. Yasko; Michael J. Yaszemski; Antonios G. Mikos

Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering

Richard G. Payne, Alan W. Yasko, Michael J. Yaszemski, Antonios G. Mikos

Orthopedic Surgery

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

Primary marrow stromal osteoblasts were temporarily encapsulated in gelatin microspheres. They were cultured for 28 days and compared to nonencapsulated control cells in assays for cell number, proliferation, and osteoblastic phenotypic expression. Results show that in all assays, encapsulated cells had values similar to those of control cells throughout the 28 day study. This study indicates that this encapsulation method is a promising initial step in allowing cells to be incorporated into an injectable, biodegradable polymeric composite for bone tissue engineering.

Original language	English (US)
Pages (from-to)	LL1.7.1-LL1.7.5
Journal	Materials Research Society Symposium - Proceedings
Volume	662
State	Published - 2001
Event	Biomaterials for Drug Delivery and Tissue Engineering - Boston, MA, United States Duration: Nov 27 2000 → Nov 29 2000

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering",

abstract = "Primary marrow stromal osteoblasts were temporarily encapsulated in gelatin microspheres. They were cultured for 28 days and compared to nonencapsulated control cells in assays for cell number, proliferation, and osteoblastic phenotypic expression. Results show that in all assays, encapsulated cells had values similar to those of control cells throughout the 28 day study. This study indicates that this encapsulation method is a promising initial step in allowing cells to be incorporated into an injectable, biodegradable polymeric composite for bone tissue engineering.",

author = "Payne, {Richard G.} and Yasko, {Alan W.} and Yaszemski, {Michael J.} and Mikos, {Antonios G.}",

year = "2001",

language = "English (US)",

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pages = "LL1.7.1--LL1.7.5",

journal = "Materials Research Society Symposium - Proceedings",

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publisher = "Materials Research Society",

note = "Biomaterials for Drug Delivery and Tissue Engineering ; Conference date: 27-11-2000 Through 29-11-2000",

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T1 - Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering

AU - Payne, Richard G.

AU - Yasko, Alan W.

AU - Yaszemski, Michael J.

AU - Mikos, Antonios G.

PY - 2001

Y1 - 2001

N2 - Primary marrow stromal osteoblasts were temporarily encapsulated in gelatin microspheres. They were cultured for 28 days and compared to nonencapsulated control cells in assays for cell number, proliferation, and osteoblastic phenotypic expression. Results show that in all assays, encapsulated cells had values similar to those of control cells throughout the 28 day study. This study indicates that this encapsulation method is a promising initial step in allowing cells to be incorporated into an injectable, biodegradable polymeric composite for bone tissue engineering.

AB - Primary marrow stromal osteoblasts were temporarily encapsulated in gelatin microspheres. They were cultured for 28 days and compared to nonencapsulated control cells in assays for cell number, proliferation, and osteoblastic phenotypic expression. Results show that in all assays, encapsulated cells had values similar to those of control cells throughout the 28 day study. This study indicates that this encapsulation method is a promising initial step in allowing cells to be incorporated into an injectable, biodegradable polymeric composite for bone tissue engineering.

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M3 - Conference article

AN - SCOPUS:0035559968

SN - 0272-9172

VL - 662

SP - LL1.7.1-LL1.7.5

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - Biomaterials for Drug Delivery and Tissue Engineering

Y2 - 27 November 2000 through 29 November 2000

ER -

Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering

Abstract

ASJC Scopus subject areas

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